RECK and ZNF704

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RECK	ZNF704
Description		reversion inducing cysteine rich protein with kazal motifs	zinc finger protein 704
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Side Of Membrane Wnt Signalosome	Nucleus
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Coreceptor Activity Wnt-protein Binding Peptidase Inhibitor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Extracellular Matrix Disassembly Wnt Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization	Regulation Of Transcription By RNA Polymerase II
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Generic Transcription Pathway
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)	Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851) Blood urea nitrogen levels ( 31152163) Cannabis use ( 30150663) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Pre-treatment viral load in HIV-1 infection ( 31219150) Zinc levels ( 26025379)
Interacting Genes		45 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 DYRK1A EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL RPS6KA1 SIGMAR1 SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704	1 interacting genes: RECK
Entrez ID		8434	619279
HPRD ID		05567	18864
Ensembl ID		ENSG00000122707	ENSG00000164684
Uniprot IDs		A8K9D8 O95980 Q6P9E2	E5RGL7 Q6ZNC4
PDB IDs		8TZP
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament	Wnt Signalosome Regulation Of Establishment Of Blood-brain Barrier Blood Vessel Maturation Metalloendopeptidase Inhibitor Activity Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Extracellular Matrix Organization Regulation Of Extracellular Matrix Disassembly Embryonic Forelimb Morphogenesis Wnt-protein Binding Sprouting Angiogenesis Forelimb Morphogenesis Embryo Implantation Endopeptidase Inhibitor Activity Coreceptor Activity Regulation Of Extracellular Matrix Organization Embryonic Limb Morphogenesis Serine-type Endopeptidase Inhibitor Activity Limb Morphogenesis Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Peptidase Inhibitor Activity Side Of Membrane Positive Regulation Of Wnt Signaling Pathway Developmental Maturation Extracellular Matrix Organization Regulation Of Canonical Wnt Signaling Pathway Extracellular Structure Organization Wnt Signaling Pathway Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Wnt Signaling Pathway Angiogenesis Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion
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