PCGF5 and CBX8

Number of citations of the paper that reports this interaction (PubMedID 21282530)
78

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		PCGF5	CBX8
Description		polycomb group ring finger 5	chromobox 8
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GO Annotations	Cellular Component	X Chromosome Nucleus Nucleoplasm Golgi Apparatus Centrosome PcG Protein Complex PRC1 Complex	Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H2AK119 Ubiquitin Ligase Activity	Chromatin Binding Single-stranded RNA Binding Protein Binding Histone H3K27me3 Reader Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Random Inactivation Of X Chromosome	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Cellular Response To Hydrogen Peroxide
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Plateletcrit ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		9 interacting genes: CBX7 CBX8 DHX57 PRMT6 QKI TRAF2 TRIM8 UBE2D3 USP10	93 interacting genes: ABLIM3 BACH2 BANP BMI1 CALCOCO2 CARD10 CARD9 CCDC136 CCDC57 CEP70 DVL3 EEF1G FHL3 FSD2 FXR1 GIGYF1 GOLGA2 GOLGA6L9 GPRASP2 GRIPAP1 H3-3A H3-4 H3C1 H3C14 HAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 JADE2 JAKMIP1 KANK2 KAT5 KAT7 KCTD9 KIFC3 KRT31 KRT34 KRT40 LSM2 LZTS2 MB21D2 MCC MDFI MID2 MLLT1 MLLT3 MTUS2 NAB2 PAXIP1 PCGF5 PHACTR1 PIBF1 PICK1 PIH1D2 PLEKHF2 PNMA1 PNMA2 POLR1C PRDM6 PRKAR1B RASSF3 RING1 RNF2 RPGRIP1 RPTOR SESTD1 SETDB1 SOX5 TAX1BP1 TEPSIN TFCP2 TFIP11 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC22D4 TSGA10 TTC23 TXNIP UNC119 USH1G USP11 USP7 VIM ZBTB14 ZBTB8A ZBTB9 ZNF185 ZRANB1
Entrez ID		84333	57332
HPRD ID		17825	13006
Ensembl ID		ENSG00000180628	ENSG00000141570
Uniprot IDs		Q86SE9	Q9HC52
PDB IDs		4S3O	2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PRC1 Complex Regulation Of Metabolic Process PcG Protein Complex Stress Granule Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Ubiquitination Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Protein Polyubiquitination TORC2 Complex Disassembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process MRNA Stabilization Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Chromatin Organization Internal N(7)-methylguanine-containing RNA Reader Activity Histone H2AR3 Methyltransferase Activity Ubiquitin Protein Ligase Activity Regulation Of Macromolecule Metabolic Process Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stress Granule Assembly Myofibroblast Contraction Negative Regulation Of MiRNA Catabolic Process Histone H3R2 Methyltransferase Activity Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Histone Arginine N-methyltransferase Activity Response To Stress Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex DNA Repair	Protein Binding Chromatin Organization Cytoskeleton Chromatin Remodeling Cytoplasm PRC1 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Histone H4K16 Acetyltransferase Activity PcG Protein Complex Cytosol Epigenetic Regulation Of Gene Expression Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Zinc Ion Binding Negative Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Metabolic Process Microtubule Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Autophagy Positive Regulation Of Protein Modification Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Centrosome Histone Acetyltransferase Complex CBM Complex Regulation Of Metabolic Process Organelle Organization Cellular Component Assembly Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Autophagy Nucleoplasm Regulation Of Transcription By RNA Polymerase II Microtubule Binding Organelle Assembly Nucleosome Sex Chromatin
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