NUDT16L1 and METTL17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUDT16L1	METTL17
Description		nudix hydrolase 16 like 1	methyltransferase like 17
Image
GO Annotations	Cellular Component	Nucleus	Nucleoplasm Mitochondrion Mitochondrial Matrix Intracellular Organelle Lumen
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding Protein Homodimerization Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Phosphodiesterase Decapping Endonuclease Activity	Protein Binding Methyltransferase Activity Small Molecule Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Mitochondrial Ribosome Binding S-adenosyl-L-methionine Binding
	Biological Process	MRNA Catabolic Process Sno(s)RNA Catabolic Process Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Translation Ribosomal Small Subunit Biogenesis Mitochondrial Small Ribosomal Subunit Assembly
Pathways
Drugs
Diseases
GWAS			Degraded stimulus continuous performance test score ( 31596458)
Interacting Genes		53 interacting genes: APP CABP2 CEBPA ERBB2 FBXO7 HNRNPF HNRNPH1 IKZF3 INCA1 KRT31 LRRK1 METTL17 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR18B MIR200C MIR21 MIR25 MIR31 MIR34A MIR34B MIR363 MIR451A MIR7-3 MIR9-1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4L NEK6 NTAQ1 PNMA1 RECK SMARCD1 TRAF2 TRAF4 TRAF7 TRIM68 ZRANB1	22 interacting genes: ATXN1 ATXN1L CALCOCO2 CARD10 CBY2 CEP70 KRT34 KRT40 MAPK6 MDFI MEOX2 MID2 MTUS2 NUDT16L1 NUTM1 PNMA1 SF3B4 TFIP11 THTPA TRAF1 TRIP6 VCP
Entrez ID		84309	64745
HPRD ID		15309	13379
Ensembl ID		ENSG00000168101	ENSG00000165792
Uniprot IDs		B2RD96 K7ENA3 Q9BRJ7 W4VSQ8	A0A0S2Z5L8 Q9H7H0
PDB IDs		3KVH 5ZCJ 6CO1 6D0L 8U3S	8CSP 8CSQ 8CSR 8CSS 8CST 8CSU
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Biosynthetic Process RNA Destabilization Negative Regulation Of Metabolic Process Positive Regulation Of MRNA Catabolic Process Extracellular Vesicle Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Angiogenesis Regulation Of Vasculature Development Extracellular Space Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus	POZ Domain Binding Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
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