CASP10 and PHF20L1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CASP10	PHF20L1
Description		caspase 10	PHD finger protein 20 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Nucleus Nucleoplasm NSL Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Methylation-dependent Protein Binding
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Protein Maturation Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Alanine aminotransferase levels ( 33547301) Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 23770605 28165464) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)	Body fat percentage ( 31752434) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Thyroid stimulating hormone levels ( 32769997) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		36 interacting genes: BFAR BID BMPR2 CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 ERBB4 FADD IGFBP2 NFKBIL1 NPTX1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP SCARB1 TNFRSF1A TRAF1 XIAP YBX3	10 interacting genes: APP CASP10 ELAVL4 KDM1A LRRK2 LYAR TERT UBC WWP1 ZNF471
Entrez ID		843	51105
HPRD ID		03458	15125
Ensembl ID		ENSG00000003400	ENSG00000129292
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	A0A0A0MQS0 A0A0A8K9A6 A8MW92 F8W9L8 Q9H8G4
PDB IDs			2EQM 2EQU 2JTF 6L0X 6L10 6L1C 6L1F 6L1I 6L1P
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Peptidase Activity Death Receptor Binding Extrinsic Apoptotic Signaling Pathway Protein Processing Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Execution Phase Of Apoptosis Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Necroptotic Process Cellular Response To Mechanical Stimulus Protein Maturation Regulation Of Programmed Necrotic Cell Death Cell Surface Receptor Signaling Pathway Peptidase Activity Cellular Response To Staurosporine Proteolysis Epithelial Cell Apoptotic Process Regulation Of Signal Transduction Glial Cell Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Response To Mechanical Stimulus Response To Anesthetic Ripoptosome CD95 Death-inducing Signaling Complex Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Defense Response Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Response To Stress Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Cobalt Ion Regulation Of Apoptotic Signaling Pathway Fibroblast Apoptotic Process	Golgi-associated Vesicle Growth Cone Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Perikaryon Regulation Of Apoptotic Signaling Pathway Response To Catecholamine Response To Manganese Ion Macromolecule Metabolic Process Positive Regulation Of Endocytosis Telomeric DNA Binding Neuron Maturation Regulation Of Intrinsic Apoptotic Signaling Pathway Locomotory Behavior Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Cell Projection Morphogenesis Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Cellular Response To CAMP Modulation Of Excitatory Postsynaptic Potential TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex Positive Regulation Of Stem Cell Proliferation SiRNA Transcription Regulation Of Neuroblast Proliferation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Myeloid Cell Development Negative Regulation Of RNA Metabolic Process Regulation Of Endocytosis Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Wnt Signaling Pathway Acetylcholine Receptor Activator Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Response To Metal Ion
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