GINS4 and -

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GINS4	-
Description		GINS complex subunit 4	salt inducible kinase 1B (putative)
Image			No pdb structure
GO Annotations	Cellular Component	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex
	Molecular Function	Protein Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Replication DNA-templated DNA Replication
Pathways		Unwinding of DNA Unwinding of DNA	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs			Dabrafenib Fostamatinib
Diseases
GWAS			HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		13 interacting genes: - BIN3 CTNNBIP1 DMAP1 GINS2 IDO2 KIF16B LHX8 PBX4 POLA1 POLD1 POLE PPP1R13B	6 interacting genes: GINS4 LHX8 MESD PITX1 PRTFDC1 TIMM10
Entrez ID		84296	102724428
HPRD ID		11583
Ensembl ID		ENSG00000147536	ENSG00000275993
Uniprot IDs		Q9BRT9	P57059
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
Enriched GO Terms of Interacting Partners?		DNA Polymerase Activity DNA-directed DNA Polymerase Activity DNA Replication Proofreading DNA Synthesis Involved In DNA Repair Leading Strand Elongation DNA Replication DNA-templated DNA Replication Nucleotide-excision Repair, DNA Gap Filling DNA Repair DNA Strand Elongation Involved In DNA Replication Nucleotidyltransferase Activity DNA Biosynthetic Process Base-excision Repair, Gap-filling DNA Strand Elongation DNA Metabolic Process DNA Damage Response 4 Iron, 4 Sulfur Cluster Binding Actin Cortical Patch Localization Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Iron-sulfur Cluster Binding Beta-catenin-ICAT Complex Indoleamine 2,3-dioxygenase Activity Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Unidimensional Cell Growth Tryptophan 2,3-dioxygenase Activity Mitotic DNA Replication Initiation Nucleobase-containing Compound Biosynthetic Process Alpha DNA Polymerase:primase Complex Error-free Translesion Synthesis Delta DNA Polymerase Complex Epsilon DNA Polymerase Complex Single-stranded DNA 3'-5' DNA Exonuclease Activity GINS Complex Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Ethanol L-tryptophan Catabolic Process To Kynurenine Cellular Response To Stress DNA Replication, Synthesis Of Primer Nucleotide-excision Repair Complex Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II	Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering TIM22 Mitochondrial Import Inner Membrane Insertion Complex Mitochondrial Intermembrane Space Chaperone Complex Purine Nucleoside Monophosphate Catabolic Process Purine Ribonucleoside Salvage Hypoxanthine Phosphoribosyltransferase Activity Nucleoside Salvage Guanine Salvage Guanine Metabolic Process GMP Catabolic Process Purine Nucleobase Biosynthetic Process CMG Complex Double-strand Break Repair Via Break-induced Replication GINS Complex
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