SYT3 and IQSEC1

Number of citations of the paper that reports this interaction (PubMedID 30545844)
0

Data Source:
BioGRID (pull down)

		SYT3	IQSEC1
Description		synaptotagmin 3	IQ motif and Sec7 domain ArfGEF 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Exocytic Vesicle	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Synaptic Vesicle Postsynaptic Density Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding Calcium Ion Sensor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Positive Regulation Of Vesicle Fusion Positive Regulation Of Dendrite Extension	Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Positive Regulation Of Keratinocyte Migration Dendritic Spine Development Positive Regulation Of Focal Adhesion Disassembly
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Superior frontal gyrus volume ( 31530798) Waist circumference ( 28552196)	Body mass index ( 26426971) Motor coordination ( 34177493) Periodontitis (DPAL) ( 24024966) Spondylosis ( 33332786) Systolic blood pressure ( 32902719) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: AP2A1 GRIA2 IQSEC1 KCNJ6 MRM1 SNAP25 SNCA SYNCRIP SYT5	3 interacting genes: APOE MAGEA3 SYT3
Entrez ID		84258	9922
HPRD ID		08977	11052
Ensembl ID		ENSG00000213023	ENSG00000144711
Uniprot IDs		Q9BQG1	A0A0C4DGT3 A0A3B3IRZ4 B4DGC5 Q6DN90
PDB IDs			3QWM 4C0A 5NLV 5NLY 6FNE 7VMB
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle SNARE Binding Postsynaptic Endocytic Zone Vesicle-mediated Transport In Synapse Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Synaptic Vesicle Priming Synapse Positive Regulation Of Vesicle Fusion Modulation Of Chemical Synaptic Transmission Neurotransmitter Uptake Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Import Into Cell Synaptic Vesicle Endocytosis Signaling Cell-cell Signaling Neurotransmitter Secretion Presynaptic Endocytosis Cell Communication Long-term Synaptic Potentiation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Receptor Internalization Regulation Of Transport Lipid Binding Endocytic Vesicle Membrane Neuronal Cell Body Voltage-gated Potassium Channel Complex Regulation Of Neurotransmitter Secretion Axon Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process RRNA (guanosine-2'-O-)-methyltransferase Activity Regulation Of Postsynaptic Membrane Potential Neurotransmitter Transport Response To Type II Interferon Regulated Exocytosis Establishment Of Vesicle Localization Ligand-gated Monoatomic Cation Channel Activity Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Proximal Neuron Projection RRNA (guanine) Methyltransferase Activity	Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipoprotein Transport Regulation Of Developmental Growth Negative Regulation Of Dendritic Spine Maintenance Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Very-low-density Lipoprotein Particle Clearance Multivesicular Body, Internal Vesicle Positive Regulation Of Phospholipid Efflux Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering Lipoprotein Biosynthetic Process NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Triglyceride-rich Lipoprotein Particle Clearance Phosphatidylcholine-sterol O-acyltransferase Activator Activity Positive Regulation Of Dendritic Spine Maintenance Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Plasma Lipoprotein Particle Levels Chylomicron Remnant Clearance Lipoprotein Particle Binding Trans-synaptic Signaling Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Synaptic Signaling Negative Regulation Of Cholesterol Biosynthetic Process Protein Import High-density Lipoprotein Particle Clearance Regulation Of Proteolysis Negative Regulation Of Cholesterol Metabolic Process Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Dendritic Spine Development
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