RHBDD1 and LPCAT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHBDD1	LPCAT2
Description		rhomboid domain containing 1	lysophosphatidylcholine acyltransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Lipid Droplet Plasma Membrane Membrane Organelle Subcompartment
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Calcium Ion Binding Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity Metal Ion Binding 2-acylglycerol-3-phosphate O-acyltransferase Activity Plasmalogen Synthase Activity 1-acylglycerophosphocholine O-acyltransferase Activity 1-alkylglycerophosphocholine O-acetyltransferase Activity
	Biological Process	Proteolysis Apoptotic Process Spermatogenesis Positive Regulation Of Protein Processing Cell Differentiation Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Spermatid Differentiation Positive Regulation Of Secretion Positive Regulation Of Protein Metabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation	Lipid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Platelet Activating Factor Biosynthetic Process Phospholipid Biosynthetic Process Phosphatidylcholine Acyl-chain Remodeling Membrane Organization
Pathways			Acyl chain remodelling of PC
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Kawasaki disease ( 33692975) Pulmonary function ( 17903307)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Thyroid hormone levels ( 23408906)
Interacting Genes		21 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC ITCH LPCAT2 LRRK2 MFHAS1 NEDD4 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TGFA TMEM42 TMEM86B TMIE	8 interacting genes: CREB3 EBP ERGIC3 HSD17B13 KCNJ6 RETREG3 RHBDD1 SLC71A2
Entrez ID		84236	54947
HPRD ID		13206	07913
Ensembl ID		ENSG00000144468	ENSG00000087253
Uniprot IDs		Q8TEB9	Q7L5N7
PDB IDs		5EPP
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Negative Regulation Of Autophagy Endoplasmic Reticulum Membrane Regulation Of Autophagosome Assembly Endoplasmic Reticulum Regulation Of Vacuole Organization Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Negative Regulation Of Autophagosome Assembly Positive Regulation Of Protein Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Membrane Syntaxin-1 Binding Ubiquitin-protein Transferase Activity Ether Lipid Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Neuromuscular Junction Development Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of Catabolic Process Negative Regulation Of Macroautophagy 3-beta-hydroxysteroid Dehydrogenase [NAD(P)+]/C4-decarboxylase Activity 3-beta-hydroxysteroid Dehydrogenase (NAD+)/C4-decarboxylase Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly D-lysine 5,6-aminomutase Activity Channel Inhibitor Activity Regulation Of Macroautophagy Protein Monoubiquitination Lumenal Side Of Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Macrophage Activation Plasmalogen Synthase Activity Organelle Subcompartment Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Response To Unfolded Protein Positive Regulation Of Deacetylase Activity C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Cholestenol Delta-isomerase Activity Retrograde Transporter Complex, Golgi To ER Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity Steroid Dehydrogenase Activity G-protein Activated Inward Rectifier Potassium Channel Activity Transporter Complex Endoplasmic Reticulum-autophagosome Adaptor Activity Release From Viral Latency Regulation Of Male Germ Cell Proliferation CCR1 Chemokine Receptor Binding Regulation Of Germ Cell Proliferation
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