PPIC and UBAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PPIC	UBAP1
Description		peptidylprolyl isomerase C	ubiquitin associated protein 1
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GO Annotations	Cellular Component	Cytoplasm Intracellular Membrane-bounded Organelle Extracellular Exosome	ESCRT I Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity	Protein Binding Ubiquitin Binding
	Biological Process	Protein Folding	Protein Transport Multivesicular Body Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission
Pathways			Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs		Proline
Diseases
GWAS		Aortic root size ( 19584346) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subcortical volume (MOSTest) ( 32665545)	Creatine kinase levels ( 29403010) Fruit consumption ( 32066663) Pulse pressure ( 30224653)
Interacting Genes		14 interacting genes: ARSA BANP CAPNS2 FAM25A FAM25C FAM25G LGALS3BP SGTA SGTB TRAF7 UBAP1 UBQLN1 UBQLN2 UBQLN4	6 interacting genes: ITGA5 MAP3K1 PPIC PTPN23 UBC WWP2
Entrez ID		5480	51271
HPRD ID		00459	15597
Ensembl ID		ENSG00000168938	ENSG00000165006
Uniprot IDs		P45877	A0A6G6AA68 Q9NZ09
PDB IDs		2ESL	1WGN 4AE4 5LM1
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Cerebroside-sulfatase Activity Regulation Of Cellular Response To Stress Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Targeting To Membrane Identical Protein Binding Autophagy Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Proteolysis Establishment Of Protein Localization To Organelle Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Autophagosome Assembly BAT3 Complex Binding Autophagosome Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Autophagy Calpain Complex Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Vesicle Cytosolic Proteasome Complex Regulation Of Protein Metabolic Process Negative Regulation Of ERAD Pathway	Symbiont Entry Into Host Cell Integrin Alpha5-beta1 Complex Modification-dependent Protein Catabolic Process Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Biological Process Involved In Interaction With Host Alphav-beta3 Integrin-vitronectin Complex Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Wnt Protein Secretion Regulation Of Adherens Junction Organization Regulation Of Homophilic Cell Adhesion
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