TBC1D3F and FBXL20

		TBC1D3F	FBXL20
Description		TBC1 domain family member 3F	F-box and leucine rich repeat protein 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process		Behavioral Fear Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ovarian cancer ( 23535730)	Asthma ( 31619474) Coronary artery disease ( 29212778) Creatinine levels ( 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 26831199) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung function (FVC) ( 30804560) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Microalbuminuria ( 31511532) Platelet count ( 32888494) Rapid automised naming of pictures ( 30741946) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Ulcerative colitis ( 20228799) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		5 interacting genes: CDC42 FBXL20 RAB5A RAC1 YWHAE	8 interacting genes: BAX BBC3 PGAP3 PIK3C3 PPP1R1B SKP1 TBC1D3F UBE2D1
Entrez ID		84218	84961
HPRD ID		09667	10951
Ensembl ID		ENSG00000275954	ENSG00000108306
Uniprot IDs		A6NER0	J3KTA1 Q96IG2
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Melanosome Thioesterase Binding Regulation Of Vesicle-mediated Transport Regulation Of Transport GTP-dependent Protein Binding Regulation Of Cell Projection Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Transport Phagocytosis, Engulfment Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Lamellipodium Assembly GTPase Activity Substantia Nigra Development Regulation Of Filopodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Invagination Positive Regulation Of Stress Fiber Assembly GTP Binding Regulation Of Lamellipodium Organization Non-canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development Focal Adhesion Endocytosis Dendrite Host-mediated Perturbation Of Viral Process Cytoplasmic Ribonucleoprotein Granule Phagocytic Vesicle Modulation Of Chemical Synaptic Transmission Regulation Of Neurotransmitter Secretion Cellular Localization Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Stress Fiber Assembly Regulation Of Cell Communication Glutamatergic Synapse Regulation Of Signaling Regulation Of Secretion By Cell Host-mediated Perturbation Of Symbiont Process Membrane Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Import Into Cell	Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis T Cell Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Lymphocyte Apoptotic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Release Of Cytochrome C From Mitochondria Leukocyte Apoptotic Process Regulation Of Epithelial Cell Apoptotic Process Regulation Of Lymphocyte Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Homeostatic Proliferation Positive Regulation Of Neuron Apoptotic Process BAX Complex Apoptotic Mitochondrial Changes Release Of Matrix Enzymes From Mitochondria Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage B Cell Negative Selection Positive Regulation Of Motor Neuron Apoptotic Process BAK Complex Regulation Of Response To Endoplasmic Reticulum Stress Glycolipid Metabolic Process Response To Radiation B Cell Receptor Apoptotic Signaling Pathway B Cell Homeostatic Proliferation Signal Transduction By P53 Class Mediator Phosphatidylinositol Biosynthetic Process Protein K48-linked Ubiquitination Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Regulation Of Mitochondrion Organization Regulation Of Nitrogen Utilization Apoptotic Process Involved In Mammary Gland Involution Retinal Cell Programmed Cell Death F-box Domain Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of B Cell Apoptotic Process
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