EEA1 and STX12

Number of citations of the paper that reports this interaction (PubMedID 10458612)
0

Data Source:
HPRD (in vitro)

		EEA1	STX12
Description		early endosome antigen 1	syntaxin 12
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynaptic Endosome Postsynaptic Early Endosome Glutamatergic Synapse	Golgi Membrane Phagophore Assembly Site Nucleoplasm Endosome Golgi Apparatus Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Synaptic Vesicle Membrane BLOC-1 Complex SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Vesicle Membrane Raft Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Postsynaptic Recycling Endosome
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Metal Ion Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Chemical Synaptic Transmission, Postsynaptic	Autophagosome Assembly Intracellular Protein Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Endocytic Recycling Cholesterol Efflux Vesicle Docking Protein Stabilization Regulation Of Biological Quality
Pathways		Toll Like Receptor 9 (TLR9) Cascade
Drugs		Inositol 1,3-Bisphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)
Interacting Genes		15 interacting genes: CDC73 IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 USP7 ZFYVE16	44 interacting genes: AQP6 AQP8 BCL2L13 BLOC1S6 CD79A CISD2 DNAJC5 DTX2 EBP EEA1 EPB42 ERGIC3 FAM209A FCER1G GORAB HOMER1 KASH5 LEPROTL1 LMNA MFSD6 MMGT1 NAPA NEMP1 NSG1 PDZK1IP1 PLPPR2 RIC3 SEC11C SLC10A1 SLC10A6 SLC66A2 SNAP23 SNAP25 SNAP29 STX1A STX2 STXBP5L TIMMDC1 TLCD4 TMEM14B TMEM167B TMEM31 TMEM86B TMX2
Entrez ID		8411	23673
HPRD ID		05460	06059
Ensembl ID		ENSG00000102189	ENSG00000117758
Uniprot IDs		Q15075	Q86Y82
PDB IDs		1HYI 1HYJ 1JOC 3MJH	2DNX
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Early Endosome Early Endosome Membrane Intracellular Protein Transport Vesicle Organization Endomembrane System Endosomal Transport Protein Transport Endosome GDP Binding Intracellular Transport Phagocytic Vesicle Establishment Of Protein Localization Plasma Membrane To Endosome Transport Cellular Localization Establishment Of Localization In Cell Membrane Fusion GTPase Activity Intracellular Protein Localization GTP Binding Transcytosis Endosome Organization Endocytosis Vesicle Fusion Organelle Membrane Fusion Regulation Of Vesicle-mediated Transport Organelle Fusion Synaptic Vesicle Membrane Regulation Of Cellular Component Organization Organelle Organization Import Into Cell Vesicle Docking Endocytic Vesicle G Protein Activity Nucleotide Binding Organelle Localization By Membrane Tethering Phagocytic Vesicle Membrane Membrane Docking Melanosome Endosome Membrane Regulation Of Vesicle Size Regulation Of Endocytosis Membrane Organization Regulation Of Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Clearance Positive Regulation Of Protein-containing Complex Disassembly SNAP Receptor Activity Golgi Apparatus SNARE Complex	Membrane SNARE Complex Exocytosis Membrane Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane SNAP Receptor Activity Membrane Organization Secretion By Cell Synaptic Vesicle Membrane Organization Synaptic Vesicle Priming Vesicle-mediated Transport Vesicle Fusion Syntaxin Binding Organelle Membrane Fusion Secretion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Docking Synaptic Vesicle Docking Vesicle Organization Vesicle Docking Establishment Of Localization In Cell Organelle Localization SNARE Binding Protein Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Presynaptic Active Zone Membrane Signal Release Bile Acid:sodium Symporter Activity Cellular Localization Synaptic Vesicle Exocytosis Vesicle-mediated Transport In Synapse Mitochondrial Membrane ATP-dependent Protein Binding Regulated Exocytosis Vesicle Docking Involved In Exocytosis Ammonium Channel Activity Cytoplasmic Vesicle Ammonium Transmembrane Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Presynapse Regulation Of Synaptic Vesicle Priming Water Channel Activity Tertiary Granule Membrane Intracellular Transport BLOC-1 Complex Vesicle Targeting Somatodendritic Compartment
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