OBSCN and DNAJB5

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		OBSCN	DNAJB5
Description		obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	DnaJ heat shock protein family (Hsp40) member B5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Myofibril Z Disc M Band Sarcolemma	Nucleus Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Structural Constituent Of Muscle Phosphatidylinositol-5-phosphate Binding Kinase Activity Transferase Activity Ankyrin Binding Titin Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidylinositol-4-phosphate Binding Protein Serine Kinase Activity Phosphatidylinositol Bisphosphate Binding	Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Cell Differentiation Protein Localization To M-band Sarcomere Organization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein
Pathways
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433) PR interval ( 30046033 32439900)	Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		8 interacting genes: ANK1 ANK2 BRCA1 CALM1 DNAJB5 MTDH MYH2 TTN	12 interacting genes: ANK2 CACNA1A MRFAP1 MYBPC1 NOCT OBSCN SIGMAR1 SMAD2 SMAD3 TAF1 TBPL2 TTN
Entrez ID		84033	25822
HPRD ID		10551	07106
Ensembl ID		ENSG00000154358	ENSG00000137094
Uniprot IDs		A6NGQ3	A0A7I2RN43 O75953
PDB IDs
Enriched GO Terms of Interacting Partners?		M Band Transmembrane Transporter Binding Enzyme Binding Z Disc A Band Actin-myosin Filament Sliding Muscle Filament Sliding Cytoskeletal Anchor Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Spectrin Binding Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Actin-mediated Cell Contraction Condensed Nuclear Chromosome Protein-containing Complex Sarcomere Regulation Of Action Potential Actin Filament-based Movement Protein Localization To T-tubule Structural Constituent Of Cytoskeleton ATPase Binding Protein Kinase Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Localization To M-band Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Atrial Cardiac Muscle Cell To AV Node Cell Communication Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Regulation Of Heart Rate Sarcolemma Skeletal Muscle Myosin Thick Filament Assembly Regulation Of Sequestering Of Calcium Ion Maintenance Of Epithelial Cell Apical/basal Polarity Structural Molecule Activity Ankyrin-1 Complex Regulation Of Muscle Contraction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Atrial Cardiac Muscle Cell Action Potential Potassium Channel Activator Activity Calcium-mediated Signaling SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication	M Band Protein Localization To M-band Paraxial Mesoderm Morphogenesis Sarcomere Organization Structural Constituent Of Muscle Mesoderm Morphogenesis Pericardium Development SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Titin Binding Transforming Growth Factor Beta Receptor Binding I-SMAD Binding Actomyosin Structure Organization Z Disc SMAD Protein Signal Transduction DNA-templated Transcription R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Endoderm Development MiRNA Processing RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Ureteric Bud Development Negative Regulation Of Ossification Protein Stabilization Transcription Regulator Complex Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development Mesoderm Formation Nuclear Receptor Binding Nuclear Inner Membrane Myofibril Phosphatase Binding Protein Localization To T-tubule Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Androgen Receptor Signaling Pathway NADP Phosphatase Activity NADPH Phosphatase Activity Formation Of Primary Germ Layer Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Osteoblast Differentiation
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