PLA2G10 and NOXA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLA2G10	NOXA1
Description		phospholipase A2 group X	NADPH oxidase activator 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle	Cytoplasm Cytosol Plasma Membrane Membrane NADPH Oxidase Complex
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Fertilization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonate Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Hair Follicle Morphogenesis Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Intestinal Stem Cell Homeostasis Macrophage Activation Cholesterol Homeostasis Regulation Of Macrophage Activation Erythrocyte Maturation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonate Secretion Negative Regulation Of Cholesterol Efflux Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Acrosome Reaction	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Respiratory Burst
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs		Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Cholesteryl ester levels ( 31551469)	Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		56 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE GRIN2A HGS HOXA1 HOXC8 HR HSF4 INCA1 KPRP KRTAP10-8 KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE1F LCE2A LCE2B LCE2D LCE3A LCE5A MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 PLSCR4 POU4F3 ROR2 SAXO4 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10	57 interacting genes: ACTMAP ANKRD55 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 SPMIP6 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620
Entrez ID		8399	10811
HPRD ID		04674	17644
Ensembl ID		ENSG00000069764	ENSG00000188747
Uniprot IDs		O15496	Q86UR1
PDB IDs		1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J	7CFZ
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Protein Binding Chromatin	NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Regulation Of Respiratory Burst Respiratory Burst Regulation Of Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Manchette Benzodiazepine Receptor Binding Erythrocyte Enucleation Protein Binding Intermediate Filament Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Cytokine Production Superoxide-generating NADPH Oxidase Activator Activity Intracellular Signaling Cassette Internal Protein Amino Acid Acetylation Negative Regulation Of Glial Cell Apoptotic Process Thioesterase Binding
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