PIP4K2B and RPRD1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIP4K2B	RPRD1B
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 beta	regulation of nuclear pre-mRNA domain containing 1B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Transcription Preinitiation Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding GTP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Protein Homodimerization Activity Phosphatidylinositol Kinase Activity	RNA Polymerase II Complex Binding Protein Binding Identical Protein Binding RNA Polymerase II C-terminal Domain Binding
	Biological Process	Lipid Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	RNA Polymerase II Promoter Clearance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process MRNA 3'-end Processing Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs		Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 20881960 28552196 31562340)
Interacting Genes		17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131	22 interacting genes: BIN3 CDCA8 DDIT4L EIF4ENIF1 HMG20A HMGB3 HOXC4 NUTF2 PFDN6 PIP4K2B PSMB1 RASSF3 SPG21 STAT3 STEEP1 TERF2 TNPO2 TUBGCP4 UBE2I VAX1 VPS37C WEE2-AS1
Entrez ID		8396	58490
HPRD ID		04463	08513
Ensembl ID		ENSG00000276293	ENSG00000101413
Uniprot IDs		P78356	Q9NQG5
PDB IDs		1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H 7EM1 7EM2 7EM3 7EM4 7EM5 7EM6 7EM7 7EM8 7N80 7N81	4FLA 4FU3 4HFG 4NAD 4Q94 4Q96 9B9L
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of DNA Recombination Nucleoplasm Cajal Body Regulation Of Primary Metabolic Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Identical Protein Binding Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process DNA Metabolic Process DNA Damage Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Kynureninase Activity Telomere-telomerase Complex Assembly Regulation Of DNA Metabolic Process Response To Stress Positive Regulation Of Immunoglobulin Production Double-strand Break Repair Via Nonhomologous End Joining DNA Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Type I Hypersensitivity B Cell Affinity Maturation Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Response To Vitamin B6 Nuclear Proteasome Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Immunoglobulin Production Regulation Of Metabolic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Macromolecule Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase CK2 Complex	Import Into Nucleus Protein Import Into Nucleus Nuclear Transport Nucleocytoplasmic Transport Cellular Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Intracellular Transport Protein Localization To Nucleus Protein Localization To Organelle Membrane Organization Negative Regulation Of Cell Differentiation Nuclear Import Signal Receptor Activity Establishment Of Localization In Cell Nuclear Export Negative Regulation Of Developmental Process Astrocyte Differentiation Intracellular Protein Localization Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair SUMO Conjugating Enzyme Activity Actin Cortical Patch Localization Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
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