SPRTN and RNF11

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SPRTN	RNF11
Description		SprT-like N-terminal domain	ring finger protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Speck	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Recycling Endosome Extracellular Exosome
	Molecular Function	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Proteolysis DNA Damage Response Response To UV Protein Autoprocessing Translesion Synthesis Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair Protein-DNA Covalent Cross-linking Repair	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Translesion Synthesis by POLH
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494)	Atrial fibrillation ( 29290336) Male-pattern baldness ( 28196072) QRS duration ( 21076409)
Interacting Genes		5 interacting genes: KPNA4 RNF11 UBC VCP VCPIP1	69 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 YAP1 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		83932	26994
HPRD ID		13164	09955
Ensembl ID		ENSG00000010072	ENSG00000123091
Uniprot IDs		Q9H040	Q9Y3C5
PDB IDs		5IY4 6MDW 6MDX
Enriched GO Terms of Interacting Partners?		Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Hippo Signaling Proteolysis Protein Modification Process Modification-dependent Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Proteolysis Involved In Protein Catabolic Process VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Cytoplasm Protein Quality Control BAT3 Complex Binding Positive Regulation Of Protein Deubiquitination Golgi Reassembly Endoplasmic Reticulum Membrane Fusion Dopamine Secretion Macromolecule Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Negative Regulation Of Protein Localization To Chromatin Macromolecule Catabolic Process Stress Granule Disassembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Deubiquitinase Activator Activity Catecholamine Secretion Derlin-1 Retrotranslocation Complex Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex NLS-dependent Protein Nuclear Import Complex Ubiquitin Protein Ligase Binding Regulation Of Protein Deubiquitination Positive Regulation Of Membrane Potential K48-linked Polyubiquitin Modification-dependent Protein Binding ATPase Complex Ubiquitin-modified Protein Reader Activity Cellular Response To Misfolded Protein Protein K11-linked Deubiquitination Protein Metabolic Process Positive Regulation Of Cellular Respiration Response To Misfolded Protein Positive Regulation Of ATP Biosynthetic Process Protein Tag Activity Endoplasmic Reticulum Membrane Organization	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Polyubiquitination Proteolysis Ubiquitin Binding Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Activity Cytosol Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Endosome Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Positive Regulation Of Protein Catabolic Process K63-linked Polyubiquitin Modification-dependent Protein Binding Transferase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Canonical NF-kappaB Signal Transduction Early Endosome Membrane Positive Regulation Of Protein Modification Process Autophagosome Protein-containing Complex Positive Regulation Of Post-translational Protein Modification DNA Damage Response Regulation Of Protein Ubiquitination Cytoplasm Cellular Response To Stress Extracellular Exosome
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