TAF3 and TYMS

		TAF3	TYMS
Description		TATA-box binding protein associated factor 3	thymidylate synthetase
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GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Nuclear Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding Protein Heterodimerization Activity Histone H3K4me3 Reader Activity Transcription Regulator Inhibitor Activity	MRNA Regulatory Element Binding Translation Repressor Activity Thymidylate Synthase Activity Folic Acid Binding Methyltransferase Activity Transferase Activity Transferase Activity, Transferring One-carbon Groups Sequence-specific MRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Maintenance Of Protein Location In Nucleus Positive Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Signal Transduction By P53 Class Mediator	DTMP Biosynthetic Process DTTP Biosynthetic Process Nucleotide Biosynthetic Process Negative Regulation Of Translation Methylation Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process DNA Biosynthetic Process
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription
Drugs			Raltitrexed Floxuridine Trifluridine Gemcitabine Fluorouracil Methotrexate Pemetrexed Capecitabine Thymidine monophosphate 10-Propargyl-5,8-Dideazafolic Acid Deoxyuridine monophosphate S,S-(2-Hydroxyethyl)Thiocysteine Thymectacin ANX-510 OSI-7904L Pralatrexate 2,4-Diamino-5-phenyl-6-ethylpyrimidine N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE Tegafur Tegafur-uracil
Diseases
GWAS		Asthma ( 31959851) Cadmium levels ( 26025379) Red blood cell count ( 32888494)	Leukocyte telomere length ( 31171785 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Testicular germ cell tumor ( 28604728) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		8 interacting genes: GNAL H3-4 H3C1 HMGB1 KPNA2 KPNB1 TAF10 TYMS	12 interacting genes: CDC42 EPB41L3 ITGAM NAPG NDUFV2 OCRL SH3GL2 SMCHD1 TAF3 THOC1 UPF2 YES1
Entrez ID		83860	7298
HPRD ID		19377	01774
Ensembl ID		ENSG00000165632	ENSG00000176890
Uniprot IDs		A0A8I5KR98 Q5VWG9	P04818 Q53Y97
PDB IDs		5C13 5WXG 5WXH 5XMY 6MZD 6MZL 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I 4JEF 4KPW 4O1U 4O1X 4UP1 5HS3 5WRN 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 6OJU 6OJV 6PF3 6PF4 6PF5 6PF6 6QXG 6QXH 6QYQ 6R2E 6ZXO
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Viral Life Cycle NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Protein-DNA Complex Assembly Chromatin Remodeling Chromatin Organization Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Viral Process SAGA Complex Assembly Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Regulation Of Transcription Initiation By RNA Polymerase II Adenylate Cyclase Regulator Activity Regulation Of DNA Metabolic Process Regulation Of Mismatch Repair Regulation Of DNA-templated Transcription Initiation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Viral Life Cycle Ficolin-1-rich Granule Lumen Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Apoptotic Cell Clearance Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Viral Process Mitotic Chromosome Movement Towards Spindle Pole Import Into Nucleus Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Viral Penetration Into Host Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Lateral Mesodermal Cell Differentiation Allantois Development DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process DTTP Biosynthetic Process Nucleosome Nucleosome Assembly Nucleosome Organization Spermatogonial Cell Division	Membrane Organization
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