CASP5 and PPHLN1

Number of citations of the paper that reports this interaction (PubMedID 12853457)
0

Data Source:
HPRD (in vitro)

		CASP5	PPHLN1
Description		caspase 5	periphilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Protein-containing Complex NLRP1 Inflammasome Complex	Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	RNA Binding Protein Binding
	Biological Process	Proteolysis Apoptotic Process Substantia Nigra Development Interleukin-18-mediated Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Inflammatory Response Protein Maturation Cellular Response To Mechanical Stimulus	Keratinization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Protein Localization To Heterochromatin Constitutive Heterochromatin Formation
Pathways		Pyroptosis CASP5 inflammasome assembly CASP5-mediated substrate cleavage	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS			Body size at age 10 ( 32376654) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: MAX NLRP1 PPHLN1	27 interacting genes: APP BCL2L1 CASP5 CCDC57 CDC37 CDK6 CLK1 FBXO7 FXR1 ITGB1BP2 MTUS2 NAGK OGT PAXIP1 PPL SEPTIN8 SHANK3 SNCAIP SQSTM1 SRPK2 TGM2 TOMM20 TOPBP1 TP53BP2 TSGA10 UFD1 VIM
Entrez ID		838	51535
HPRD ID		04048	10488
Ensembl ID		ENSG00000137757	ENSG00000134283
Uniprot IDs		P51878	F8W6A0 Q8NEY8
PDB IDs			6SWG
Enriched GO Terms of Interacting Partners?		Myc-Max Complex Mad-Max Complex Protein Localization To Heterochromatin Positive Regulation Of Pyroptotic Inflammatory Response Self Proteolysis NLRP3 Inflammasome Complex NLRP1 Inflammasome Complex Cysteine-type Endopeptidase Activator Activity NLRP1 Inflammasome Complex Assembly Cellular Response To UV-B Canonical Inflammasome Complex Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pyroptotic Cell Death	Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cytoplasm Regulation Of Cell Cycle Regulation Of Neuron Apoptotic Process Intracellular Membraneless Organelle Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Cytosol Glial Cell Development Scaffold Protein Binding Autophagy Of Mitochondrion Regulation Of Defense Response Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Programmed Cell Death Cytoskeleton Protein Targeting Apoptotic Process Cellular Response To Catecholamine Stimulus Astrocyte Development Presynapse Programmed Cell Death Response To Catecholamine Synapse Response To Muramyl Dipeptide Regulation Of Innate Immune Response Positive Regulation Of Mitophagy SH3 Domain Binding Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Synaptic Transmission Protein Binding Developmental Process Regulation Of Mitotic Cell Cycle Organelle Organization
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