YPEL3 and PSMA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		YPEL3	PSMA3
Description		yippee like 3	proteasome 20S subunit alpha 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Extracellular Exosome
	Molecular Function	Metal Ion Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Positive Regulation Of Cellular Senescence	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs			(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Phenethyl Isothiocyanate
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Schizophrenia ( 25056061 28991256 29483656)	Brain morphology (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		122 interacting genes: ACTMAP AIRIM APP ARMC7 ATG9A ATXN1L BCAS2 C10orf55 CABP2 CDCA4 CDKN2D COL8A1 CRYBA1 CRYBA2 CYB5R2 CYSRT1 DMRT3 DOK6 DOK7 EID2B FAM168B FANCL FGF21 FHL2 FHL3 FHL5 FNDC3B FRS3 GCA GCM2 GEM GUCD1 HDAC7 HEXIM2 HGS HNRNPH1 HOXA1 HR HSD3B7 HSPB2 HSPB2-C11orf52 INTS11 KLHL38 KRTAP13-2 KRTAP15-1 KRTAP23-1 KRTAP3-1 KRTAP3-3 KRTAP6-2 LARP4 LIMS3 LIMS4 LMO2 LONRF1 MAD2L2 MDFI MKRN3 MORN3 MYOZ1 MYOZ3 NRF1 NUFIP2 ODAM OSTF1 OTX1 PIK3R3 PITX1 PLSCR4 POLD1 POLR1C POU2AF1 PPP2CA PRKAA2 PRKAB2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 QRICH1 RBPMS RFC5 SH2D4A SHC3 SMUG1 SPAG8 SPG21 SPRYD7 SRPK2 STK16 TASOR2 TBX6 TENT5A TENT5B TEPSIN TGM7 TLE5 TLX3 TOX2 TP53INP1 TRAPPC2L TRAPPC6A TRIM10 TRIM55 TRIM63 TRIM73 TRIP6 TSC1 TSSK3 UBASH3A UBTD2 VENTX VGLL3 VWC2L WWOX ZIC1 ZNF441 ZNF76 ZNF765 ZYX	120 interacting genes: ADGRL1 APLN ATN1 ATP6V0C AURKB BTN2A2 BTRC C1orf105 CCDC69 CCL28 CDK6 CDKN1A CEBPA CIP2A CRB3 CRYAB CSNK2A1 CST2 CTBP1-DT CYBA DDX5 DGLUCY DMC1 DMRT3 DVL1 EGR1 FAM171A2 FAM218A FAM83A FBXL18 FNDC3B FOS FRAT1 GATA2 GATA3 GFI1B GORASP2 HHEX HSPB1 IKBKG ILF3 IQCE KIF1A KIRREL2 KIRREL3-AS3 KRAS KRTAP19-5 KRTAP26-1 KRTAP8-1 LASP1 LBP LETM1 LINC00908 LINC02913 MDM2 MIA2 NEU4 NOL4L-DT NPBWR2 NPPB NUMBL OLIG2 OSR2 PATL1 PCOTH PLK1 PML POMP PRELID3A PRNP PRR13 PRR3 PRRC2A PSMA1 PSMA2 PSMA4 PSMA6 PSMA7 PSMB10 PSMB5 PTPN23 PWWP2B PWWP3A RAB3IL1 RAD54L2 RAMAC RBFOX2 RERE RFT1 RTP5 RUSC1-AS1 SERF2 SF1 SH3KBP1 SLAIN1 SLC22A23 SNRPB SNRPC SNRPF SPATA8 SRPK2 STUB1 STX11 STX1A STX4 STX6 TBC1D16 TBX6 TCF7L2 TINCR TP53 TRIB3 UBD URB1-AS1 VPS37C XRN2 YPEL3 ZNF366 ZNF385C ZNF688
Entrez ID		83719	5684
HPRD ID		15683	01463
Ensembl ID		ENSG00000090238	ENSG00000100567
Uniprot IDs		P61236	A0A140VK43 P25788
PDB IDs			4R3O 4R67 5A0Q 5DSV 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7E55 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8JRI 8JRT 8JTI 8K0G 8QYJ 8QYL 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8UD9 8USB 8USC 8YIX 8YIY 8YIZ 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q 9HMN
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Response To Gamma Radiation Proteasome Complex Cellular Response To Gamma Radiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Response To Ionizing Radiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin-dependent Protein Catabolic Process Protein Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Gravity Cellular Response To Ionizing Radiation Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Molecular Function Activator Activity Macromolecule Catabolic Process Negative Regulation Of Cell Cycle Nuclear Matrix Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein Destabilization Regulation Of Protein Stability HMG Box Domain Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Hormone Metabolic Process Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process SNAP Receptor Activity Proteasomal Protein Catabolic Process Cellular Response To Actinomycin D Promoter-specific Chromatin Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Senescence
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