TRAPPC9 and TRAPPC2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, two hybrid)

		TRAPPC9	TRAPPC2
Description		trafficking protein particle complex subunit 9	trafficking protein particle complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol TRAPP Complex TRAPPII Protein Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPII Protein Complex TRAPPIII Protein Complex
	Molecular Function	Protein Binding	Protein Binding Transmembrane Transporter Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Cerebral Cortex Development Cell Differentiation Neuron Differentiation Vesicle Tethering	Skeletal System Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport COPII Vesicle Coating Vesicle Tethering
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)	Spondyloepiphyseal dysplasia tarda
GWAS		Blood pressure (smoking interaction) ( 25189868) Diastolic blood pressure ( 30578418) Disease progression in age-related macular degeneration ( 29346644) Emphysema distribution in smoking ( 27669027) Hip circumference adjusted for BMI ( 28552196) Interleukin-6 levels in HIV infection ( 33095540) Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) Pars opercularis volume ( 31530798) Pediatric non-alcoholic fatty liver disease activity score ( 28918882) Pulse pressure ( 28739976 28135244 30578418 27841878) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Response to amphetamines ( 22952603) Systolic blood pressure ( 27841878) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		4 interacting genes: APP TRAPPC12 TRAPPC2 TRAPPC3L	34 interacting genes: ABRA CLIC1 CLIC2 DAPK1 EIF3C ENO1 ENO3 EPS15L1 HLA-E INCA1 KCTD1 MBD3L1 MFHAS1 NICN1 NME4 NR5A1 PITX1 PYGM REPS1 SLC25A35 SNAPC5 SNCA TEPSIN TRAPPC3 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9 UQCC2 ZBTB38 ZNF438 ZNF655 ZRANB1
Entrez ID		83696	6399
HPRD ID		18136	02189
Ensembl ID		ENSG00000167632	ENSG00000196459
Uniprot IDs		Q96Q05	P0DI81 P0DI82 Q6IBE5
PDB IDs
Enriched GO Terms of Interacting Partners?		TRAPP Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex COPII Vesicle Coating Intracellular Transport Vesicle-mediated Transport Vesicle Tethering Golgi Vesicle Transport Vesicle Coating Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum-Golgi Intermediate Compartment Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Perinuclear Region Of Cytoplasm Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization To Kinetochore PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Kinetochore Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Centromere Complex Assembly Protein-containing Complex Assembly Axon Choice Point Recognition Golgi Apparatus	TRAPP Complex Vesicle Tethering TRAPPII Protein Complex Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity COPII Vesicle Coating Golgi Vesicle Transport Protein Binding Cis-Golgi Network Membrane Vesicle-mediated Transport Vesicle Organization Intracellular Transport Establishment Of Localization In Cell
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