ZMIZ2 and SOCS6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZMIZ2	SOCS6
Description		zinc finger MIZ-type containing 2	suppressor of cytokine signaling 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Nuclear Replication Fork	Immunological Synapse Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding SUMO Ligase Activity	Protein Binding Signaling Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II SMAD Protein Signal Transduction	Defense Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of T Cell Activation
Pathways			Regulation of KIT signaling Neddylation Negative regulation of FLT3
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Fasting glucose ( 34059833) General cognitive ability ( 29844566) Hematocrit ( 32888494) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 27863252) Red blood cell count ( 27863252)	Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes		27 interacting genes: AKAP19 AR ARSJ ASB13 BANP CPNE7 CRCP FRS3 GCM2 INTS4 KPNA4 LRRC37A11P MCPH1 MVP NBL1 PIAS3 PIN1 RANBP3 SALL2 SCAMP1 SELENOV SOCS6 SS18L1 SSX2 SUMO2 TP53 TRAPPC6A	39 interacting genes: ACVR1 AIRIM AMOT APPL1 AR BMPR1B CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 PITRM1 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		83637	9306
HPRD ID		13225	05491
Ensembl ID		ENSG00000122515	ENSG00000170677
Uniprot IDs		E7EWM3 Q8NF64	O14544
PDB IDs			2VIF
Enriched GO Terms of Interacting Partners?		Postsynaptic Cytosol	Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Migration Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Receptor Complex Protein Tyrosine Kinase Activity Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Epidermal Growth Factor Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphatidylinositol 3-kinase Binding Growth Factor Binding Regulation Of Gene Expression Kinase Activity Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I ErbB-3 Class Receptor Binding Positive Regulation Of Metabolic Process Protein Modification Process ERBB2 Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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