H2BC21 and USP46

Number of citations of the paper that reports this interaction (PubMedID 21183687)
55

Data Source:
BioGRID (enzymatic study)

		H2BC21	USP46
Description		H2B clustered histone 21	ubiquitin specific peptidase 46
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GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol Synapse Glutamatergic Synapse
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Deubiquitinase Activity
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Behavioral Fear Response Proteolysis Adult Feeding Behavior Protein Deubiquitination Regulation Of Protein Stability Regulation Of Synaptic Transmission, GABAergic Behavioral Response To Ethanol Righting Reflex Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS			Biochemical measures ( 19260141) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Height ( 31562340) Platelet count ( 29403010) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		74 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NEIL3 NEK1 NPM1 PARP10 PARP9 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMU1 SPANXN2 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1	8 interacting genes: CEP135 FXR1 GRIA1 H2AC20 H2BC21 MAPK8IP2 UBA52 UBC
Entrez ID		8349	64854
HPRD ID		03494	07507
Ensembl ID		ENSG00000184678	ENSG00000109189
Uniprot IDs		Q16778	P62068
PDB IDs		4NFT 6A7U 6KBB 6M4D 6M4G 6M4H 7BXT 7EA8 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8H1T 8SPS 8SPU 8SYP 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8YJF	5CVM 5CVN 5CVO 5L8H 6JLQ
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Histone Binding Nucleoplasm Nucleus Protein Modification Process Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Post-translational Protein Modification Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Macromolecule Metabolic Process Transferase Activity Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K18 Acetyltransferase Activity	Endocytic Vesicle Membrane Protein Tag Activity Positive Regulation Of Locomotion Involved In Locomotory Behavior Axonal Spine Amyloid-beta Binding Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Cellular Response To Amine Stimulus Regulation Of Behavior Perisynaptic Space Response To Toxic Substance Modulation Of Chemical Synaptic Transmission Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Protein Heterodimerization Activity Nucleosome Structural Constituent Of Chromatin Response To Psychosocial Stress Response To Fungicide Conditioned Place Preference Regulation Of Locomotion Involved In Locomotory Behavior Glutamate Receptor Binding Response To Sucrose Immunoglobulin Binding Response To Ammonium Ion Cellular Response To Ammonium Ion Dendritic Spine AMPA Glutamate Receptor Activity Ionotropic Glutamate Receptor Complex Learning Beta-2 Adrenergic Receptor Binding Response To Disaccharide Cellular Component Assembly Ribosome Vesicle Response To Insecticide RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle Nonassociative Learning Regulation Of Synaptic Plasticity Neuron Spine Cellular Response To Brain-derived Neurotrophic Factor Stimulus Glutamate-gated Calcium Ion Channel Activity Proximal Dendrite Cellular Response To L-glutamate Mitochondrial Outer Membrane Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Non-motile Cilium Assembly Signal Complex Assembly
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