PMFBP1 and MLKL

		PMFBP1	MLKL
Description		polyamine modulated factor 1 binding protein 1	mixed lineage kinase domain like pseudokinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cilium Motile Cilium Sperm Flagellum Cell Projection Sperm Head Sperm Head-tail Coupling Apparatus	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Spermatogenesis Spermatid Development Intracellular Protein Localization Gene Expression Regulation Of Protein Localization Protein-containing Complex Assembly	Cell Surface Receptor Signaling Pathway Programmed Cell Death Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis
Pathways			TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Body mass index (change over time) in cancer ( 28044437) Body mass index (change over time) in cancer or chronic obstructive pulmonary disease ( 28044437) Chronotype ( 30696823) Depression ( 29700475) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 31217584) Lung function (FVC) ( 30061609) Mean reticulocyte volume ( 32888494) Morning person ( 30696823) Offspring birth weight ( 31043758) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 31666285 33547301) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 31217584) Triglyceride levels ( 32203549)	Heel bone mineral density x serum urate levels interaction ( 34046847) Testicular germ cell tumor ( 23666239)
Interacting Genes		4 interacting genes: ATXN1L CMTR2 MLKL ZNF821	13 interacting genes: ANAPC11 CDK1 CEBPA CYLD ITCH NDUFB7 PMFBP1 PSMB1 RAD18 S100A10 STAMBP THOC3 USP2
Entrez ID		83449	197259
HPRD ID		10157	08752
Ensembl ID		ENSG00000118557	ENSG00000168404
Uniprot IDs		Q8TBY8	Q8NB16
PDB IDs			2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1 7JW7 7JXU 7MON 7NM2 7NM4 7NM5 8SLZ
Enriched GO Terms of Interacting Partners?		Methyltransferase Cap2 Activity Methyltransferase Cap1 Activity Execution Phase Of Necroptosis POZ Domain Binding 7-methylguanosine MRNA Capping Necroptotic Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Proliferation Protein Trimerization Necroptotic Process Protein Homotrimerization Regulation Of Hematopoietic Stem Cell Proliferation Programmed Necrotic Cell Death	Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Macromolecule Metabolic Process Protein Modification Process Nucleoplasm Regulation Of Cell Cycle K63-linked Deubiquitinase Activity Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Proteolysis Protein K63-linked Deubiquitination Positive Regulation Of Chromosome Segregation Regulation Of Necroptotic Process Cyclin Binding Negative Regulation Of JNK Cascade Regulation Of Programmed Necrotic Cell Death Protein Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Type I Interferon Production Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Rad6-Rad18 Complex Protein Monoubiquitination Positive Regulation Of Cell Cycle Process Centrosome Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Vitamin B2 C/EBP Complex Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process AnxA2-p11 Complex Protein Autoubiquitination Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity CHOP-C/EBP Complex Protein Linear Deubiquitination Cysteine-type Deubiquitinase Activity Hippocampal Neuron Apoptotic Process Ubiquitin Protein Ligase Activity
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