H2AC16 and GADD45A

Number of citations of the paper that reports this interaction (PubMedID 10022855)
86

Data Source:
HPRD (in vivo)

		H2AC16	GADD45A
Description		H2A clustered histone 16	growth arrest and DNA damage inducible alpha
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GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	DNA Binding Protein Binding Enzyme Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Heterochromatin Formation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Apoptotic Process DNA Damage Response Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS			Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		5 interacting genes: BRD7 CRP GADD45A SAP30 TERF2IP	69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4C16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135
Entrez ID		8332	1647
HPRD ID		09103	00528
Ensembl ID		ENSG00000276903	ENSG00000116717
Uniprot IDs		A4FTV9 P0C0S8	A5JUZ3 P24522
PDB IDs		4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7BG9 7E8D 7JO9 7JOA 7TAN 7U50 7U51 7U52 7U53 7UV9 8ATF 8AV6 8GUI 8GUJ 8GUK 8OFF 8QZM 8VOB 8VWS 8VWT 8VWU 8VWV 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM	2KG4
Enriched GO Terms of Interacting Partners?		Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Developmental Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Choline Binding Regulation Of Developmental Process Negative Regulation Of Peptidyl-serine Phosphorylation Transcription Corepressor Activity Histone H3K14ac Reader Activity Regulation Of Chromosome Organization Regulation Of DNA Repair Protection From Non-homologous End Joining At Telomere Shelterin Complex Negative Regulation Of Macromolecule Metabolic Process Complement Component C1q Complex Binding Positive Regulation Of DNA Metabolic Process Nuclear Telomere Cap Complex Virion Binding Negative Regulation Of Metabolic Process G-rich Strand Telomeric DNA Binding Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance In Response To DNA Damage Low-density Lipoprotein Particle Binding Opsonization Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Locomotion Regulation Of RNA Biosynthetic Process RSC-type Complex Positive Regulation Of Superoxide Anion Generation Regulation Of Phosphorylation Negative Regulation Of Lipid Storage	Cellular Response To UV Response To UV Cellular Response To Light Stimulus Protein Kinase Binding Stress-induced Premature Senescence Molecular Function Activator Activity Nucleoplasm Positive Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Radiation Regulation Of Heart Growth Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Glucose Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Heart Growth Cyclin B1-CDK1 Complex PCNA-p21 Complex Nucleus Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Chromatin Organization Structural Constituent Of Chromatin Response To UV-C Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Extracellular Exosome Identical Protein Binding Cytosol Positive Regulation Of Organ Growth Regulation Of Developmental Growth Regulation Of Organ Growth Protein Localization To Organelle Centrosome Cycle Response To Light Stimulus Cellular Response To Actinomycin D Negative Regulation Of Biosynthetic Process Hexose Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Protein Binding Nucleosome Assembly Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Actinomycin D
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