SYN3 and SYN1

Number of citations of the paper that reports this interaction (PubMedID 10358015)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SYN3	SYN1
Description		synapsin III	synapsin I
Image			No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Postsynaptic Density Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Synaptonemal Complex Golgi Apparatus Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Cell Body Synapse Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Presynapse Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Actin Binding Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Synaptic Transmission, GABAergic Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Synaptic Vesicle Cycle	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Sensory processing of sound by inner hair cells of the cochlea
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819) Alzheimer's disease progression score ( 29860282) Benign prostatic hyperplasia ( 30988330) Chronic obstructive pulmonary disease ( 30804561) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Heel bone mineral density ( 30598549) Height ( 20881960 21998595 25282103 25429064 31562340) Interleukin-6 levels ( 22205395) Intracranial aneurysm ( 29531279) Intraocular pressure ( 29785010 31959993 30054594 29617998) Metabolite levels ( 23823483) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 31170924) Trunk fat mass adjusted for trunk lean mass ( 32239398)
Interacting Genes		8 interacting genes: C9orf72 MORF4L1 MORF4L2 NOS1AP PIAS2 SNCA SYN1 SYN2	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		8224	6853
HPRD ID		04083	02433
Ensembl ID		ENSG00000185666	ENSG00000008056
Uniprot IDs		O14994 Q17R54 Q59EX7	P17600
PDB IDs		2P0A
Enriched GO Terms of Interacting Partners?		Neurotransmitter Secretion Synaptic Vesicle Cycle Vesicle-mediated Transport In Synapse Neurotransmitter Transport Synaptic Vesicle Clustering Vesicle Localization Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Membrane Synaptic Vesicle Signal Release Regulation Of Exocytosis NuA4 Histone Acetyltransferase Complex Negative Regulation Of Exocytosis Presynapse Synapse Organization Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chemical Synaptic Transmission Response To Desipramine Negative Regulation Of Norepinephrine Uptake Trans-synaptic Signaling Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Synaptic Signaling Synapse Positive Regulation Of DNA Recombination Axon Secretion By Cell Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Neurotransmitter Secretion Regulated Exocytosis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Organelle Localization Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Junction Organization Schaffer Collateral - CA1 Synapse Positive Regulation Of Double-strand Break Repair Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Secretion Negative Regulation Of Chaperone-mediated Autophagy Vesicle-mediated Transport Nucleosome Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Dopamine Metabolic Process Growth Cone	Cytosol Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Biological Quality Regulation Of Organelle Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Postsynaptic Density Regulation Of Cellular Localization Presynaptic Endocytosis Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Cytoplasm Regulation Of Protein-containing Complex Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Neurotrophin TRKA Receptor Binding Protein Serine Kinase Activity Protein Kinase Activity Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Component Size Cellular Response To Nutrient Levels Protein Serine/threonine Kinase Activity Glutamatergic Synapse Actin Filament-based Process Cytoskeleton Organization Regulation Of Developmental Process Regulation Of Neuron Projection Development Kinase Activity Regulation Of Innate Immune Response Regulation Of Transport Cell Junction Organization Response To Growth Factor Regulation Of Heart Contraction Positive Regulation Of Protein-containing Complex Assembly
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