LZTR1 and KDM2B

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		LZTR1	KDM2B
Description		leucine zipper like post translational regulator 1	lysine demethylase 2B
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane	Nucleus Nucleoplasm Chromosome Nucleolus PcG Protein Complex
	Molecular Function	Protein Binding Small GTPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity RNA Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity RRNA Binding Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K36me/H3K36me2 Demethylase Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Spermatogenesis Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Initiation Of Neural Tube Closure Positive Regulation Of Cell Growth Forebrain Development Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			HDMs demethylate histones
Drugs
Diseases
GWAS			Adult body size ( 32376654) Fasting glucose ( 34059833) Hand grip strength ( 29691431) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	9 interacting genes: CEBPE CREBBP FOS H3C1 KAT5 LZTR1 MTRFR TCTN2 UBE2D1
Entrez ID		8216	84678
HPRD ID		08992	12362
Ensembl ID		ENSG00000099949	ENSG00000089094
Uniprot IDs		A0A384NL67 Q8N653	B4DSN4 Q8NHM5
PDB IDs			4O64 5JH5 6BVA 8HCU
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity	Peptide Lactyltransferase (CoA-dependent) Activity Cellular Response To Nutrient Levels Peptidyl-lysine Acetylation Acetyltransferase Activity Histone Acetyltransferase Complex Response To Nutrient Levels Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Protein Acetylation Integrated Stress Response Signaling Transcription Regulator Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Medium-term Memory Cellular Response To Prolactin Histone H2AK5 Acetyltransferase Activity Positive Regulation Of DNA Recombination Organelle Disassembly Regulation Of Double-strand Break Repair Via Homologous Recombination Intracellular Signal Transduction Histone H3K27 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Chromatin Cellular Response To Lipid Positive Regulation Of Double-strand Break Repair Chromatin Binding Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Response To Radiation Response To Prolactin Conditioned Taste Aversion Histone H2A Acetyltransferase Activity Translation Release Factor Activity, Codon Specific Nucleosome RNA Polymerase II Transcription Regulator Complex Piccolo Histone Acetyltransferase Complex Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Transcription By RNA Polymerase II Myeloid Leukocyte Differentiation Regulation Of DNA Recombination MRF Binding Regulation Of Double-strand Break Repair Recombinational Repair Positive Regulation Of DNA Repair Acyltransferase Activity Positive Regulation Of Aggrephagy Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation
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