CABLES2 and CDK3

Number of citations of the paper that reports this interaction (PubMedID 11955625)
0

Data Source:
HPRD (in vitro, in vivo)

		CABLES2	CDK3
Description		Cdk5 and Abl enzyme substrate 2	cyclin dependent kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity
	Biological Process	Cell Division Regulation Of Cell Cycle	G1/S Transition Of Mitotic Cell Cycle DNA Damage Response Signal Transduction Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Cell Division
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Colorectal cancer ( 29471430) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: ABL1 CDK3 CDK5 TP53	40 interacting genes: APP CABLES1 CABLES2 CCNA2 CCNC CCND3 CCNE1 CCNE2 CCNH CCNI CDC37 CDKN1A CDKN1B CDKN3 CKS2 E2F1 E2F2 E2F3 FOXJ1 FOXP2 FRS2 KIR3DL1 LHX3 LHX4 MEOX2 NAP1L1 NEDD4L NELFA OR2G6 OTX2 PAX5 PAX6 PAX8 PPARA RACGAP1 RB1 SPDYE4 STN1 TRIM55 TRIM63
Entrez ID		81928	1018
HPRD ID		12994	00446
Ensembl ID		ENSG00000149679	ENSG00000250506
Uniprot IDs		Q9BTV7	Q00526
PDB IDs			7XQK 8H4R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cellular Senescence Negative Regulation Of Cell Cycle T Cell Differentiation In Thymus Regulation Of Autophagy Regulation Of Cell Growth Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cerebellum Development Regulation Of Cell Cycle Phase Transition Cellular Senescence T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Axon Extension Regulation Of Mitotic Cell Cycle Protein Kinase Activity P53 Binding Regulation Of Growth Associative Learning Regulation Of Fibroblast Proliferation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Post-translational Protein Modification Hematopoietic Or Lymphoid Organ Development Kinase Activity Protein Localization To Cytoplasmic Microtubule Plus-end Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Glial Cell Differentiation Lymphocyte Activation Involved In Immune Response Mononuclear Cell Proliferation Cell Population Proliferation Lymphocyte Proliferation Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cytosolic Calcium Ion Concentration Transitional One Stage B Cell Differentiation Regulation Of Cell Development T Cell Differentiation Cellular Response To Oxygen-containing Compound DNA Damage Response Cell Activation Involved In Immune Response	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Binding Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Rb-E2F Complex Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Division Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Regulation Of Gene Expression Epithelial Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Tissue Regeneration Medial Motor Column Neuron Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Phase Transition DNA Binding Positive Regulation Of Mitotic Cell Cycle Cyclin E1-CDK2 Complex Regulation Of Protein Kinase Activity
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