LAS1L and PELP1

Number of citations of the paper that reports this interaction (PubMedID 22872859)
53

Data Source:
BioGRID (affinity chromatography technology, pull down)

		LAS1L	PELP1
Description		LAS1 like ribosome biogenesis factor	proline, glutamate and leucine rich protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane MLL1 Complex Las1 Complex	Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane MLL1 Complex
	Molecular Function	RNA Binding Endonuclease Activity Protein Binding Hydrolase Activity	Chromatin Binding RNA Binding Protein Binding SUMO Binding
	Biological Process	Maturation Of 5.8S RRNA Maturation Of LSU-rRNA RRNA Processing	RRNA Processing Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estrogen Stimulus
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol PTK6 Expression
Drugs
Diseases
GWAS			Eosinophil count ( 29403010)
Interacting Genes		3 interacting genes: FILNC1 PELP1 SUMO2	28 interacting genes: AR BAG6 BCAS3 BLOC1S1 CREBBP EP300 ESR1 ESR2 H1-1 H2AC20 H2BC21 H3-3A H4C1 HGS LAS1L NFKB1 NR3C1 PTEN RB1 SENP3 SMAD9 SNCA SRC STAT3 SUMO2 TOM1L1 TP53 USP7
Entrez ID		81887	27043
HPRD ID		06519	10144
Ensembl ID		ENSG00000001497	ENSG00000141456
Uniprot IDs		A0A7I2V3R6 A0A7I2V653 A0A7I2YQI7 Q9Y4W2	B4DEX7 B4DR36 C9JFV4 E7EV54 Q8IZL8
PDB IDs		8FL2 8FL3 8FL4	7UWF 8FL2 8FL3 8FL4
Enriched GO Terms of Interacting Partners?			Transcription Coactivator Binding Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Estrogen Response Element Binding Positive Regulation Of Transcription By RNA Polymerase II Chromatin Transcription Regulator Complex Chromatin Remodeling Peptidyl-lysine Acetylation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Intracellular Signal Transduction Nuclear Receptor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Primary Metabolic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Stability Steroid Binding Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA Binding Enzyme Binding Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Positive Regulation Of RNA Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Acetylation Structural Constituent Of Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Response To Hormone Negative Regulation Of Biosynthetic Process
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