MED25 and MED6

Number of citations of the paper that reports this interaction (PubMedID 17641689)
43

Data Source:
HPRD (in vivo)

		MED25	MED6
Description		mediator complex subunit 25	mediator complex subunit 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Core Mediator Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coactivator Binding Protein Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding	Transcription Coactivator Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Mediator Complex Assembly	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood trace element (Se levels) ( 23720494)
Interacting Genes		38 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SENP3 SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2	16 interacting genes: BCL6 CEBPA CTDP1 ESR1 ESR2 MED25 MED8 MED9 PARP1 RARA SMAD1 SMAD2 SMARCA4 SREBF1 SUZ12 TARDBP
Entrez ID		81857	10001
HPRD ID		14380	04284
Ensembl ID		ENSG00000104973	ENSG00000133997
Uniprot IDs		M0QZQ2 Q71SY5	A0A087WYL7 O75586
PDB IDs		2KY6 2L23 2L6U 2XNF 7EMF 7LBM 8GXQ 8GXS 8T9D	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nuclear Receptor Activity Core Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Mediator Complex Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription Coregulator Activity Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Intracellular Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleoplasm Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway COPII Vesicle Coating Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription	Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Preinitiation Complex Assembly Sequence-specific DNA Binding Chromatin Protein-containing Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Developmental Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly Negative Regulation Of Macromolecule Metabolic Process Nucleus Nuclear Receptor Activity Transcription By RNA Polymerase II DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process
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