TLR10 and F8A1

Number of citations of the paper that reports this interaction (PubMedID 16482509)
45

Data Source:
HPRD (two hybrid)

		TLR10	F8A1
Description		toll like receptor 10	coagulation factor VIII associated 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Nucleus Cytoplasm Endosome Early Endosome Nuclear Body
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding	Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Innate Immune Response Cellular Response To Bacterial Lipopeptide	Vesicle Cytoskeletal Trafficking Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54	6 interacting genes: DNMT3A HTT MTNR1A SH3GLB1 SNTA1 TLR10
Entrez ID		81793	8263
HPRD ID		05884	02374
Ensembl ID		ENSG00000174123	ENSG00000288722
Uniprot IDs		Q9BXR5	P23610
PDB IDs		2J67	6EZ8 6X9O 7DXJ 7DXK 8SAH 8VLX 8W15
Enriched GO Terms of Interacting Partners?		Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Cellular Response To Triacyl Bacterial Lipopeptide Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Interleukin-6 Production Detection Of Bacterial Lipoprotein Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Toll-like Receptor Signaling Pathway Toll-like Receptor Binding Positive Regulation Of Interleukin-8 Production Activation Of Innate Immune Response Myeloid Cell Development Inflammatory Response Cellular Response To Bacterial Lipopeptide Regulation Of Interleukin-8 Production Neutrophil Activation Involved In Immune Response Response To Bacterial Lipoprotein Detection Of Molecule Of Bacterial Origin Positive Regulation Of Interleukin-6 Production Positive Regulation Of Innate Immune Response Innate Immune Response NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-activating Signaling Pathway Myeloid Leukocyte Activation Defense Response To Symbiont Defense Response To Other Organism Megakaryocyte Development Defense Response Regulation Of Inflammatory Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Neutrophil Activation Regulation Of Innate Immune Response Positive Regulation Of Defense Response Detection Of Biotic Stimulus Hemopoiesis Leukocyte Activation Involved In Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Regulation Of Neutrophil Migration	Positive Regulation Of Cellular Response To Hypoxia Protein-cysteine Methyltransferase Activity Cellular Response To Bisphenol A Identical Protein Binding DNA (cytosine-5-)-methyltransferase Activity Regulation Of CAMKK-AMPK Signaling Cascade Transmembrane Transporter Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Macroautophagy Positive Regulation Of Organelle Assembly Positive Regulation Of Autophagy Positive Regulation Of Aggrephagy Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Protein-containing Complex Positive Regulation Of CAMKK-AMPK Signaling Cascade Melatonin Receptor Activity Syntrophin Complex 'de Novo' Post-translational Protein Folding Positive Regulation Of Membrane Tubulation Autophagic Cell Death Protein Localization To Vacuolar Membrane Toll-like Receptor 2 Binding Regulation Of Macroautophagy Receptor Complex Autosome Genomic Imprinting Response To Bisphenol A Cell Death Apoptotic Process Programmed Cell Death Vocal Learning Phosphatidylinositol 3-kinase Activator Activity Lipopeptide Binding Unmethylated CpG Binding Profilin Binding Observational Learning Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Organelle Assembly Lysophosphatidic Acid Acyltransferase Activity 'de Novo' Protein Folding Cellular Response To Bacterial Lipopeptide Regulation Of Monoatomic Ion Transmembrane Transport Nitric-oxide Synthase Binding Response To Bacterial Lipoprotein Transposable Element Silencing By PiRNA-mediated DNA Methylation Response To Vitamin A XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Cellular Response To Ethanol Auditory Behavior
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