MADCAM1 and CD44

Number of citations of the paper that reports this interaction (PubMedID 2474557)
49

Data Source:
HPRD (in vitro)

		MADCAM1	CD44
Description		mucosal vascular addressin cell adhesion molecule 1	CD44 molecule (IN blood group)
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Golgi Apparatus Cytosol Plasma Membrane Microvillus Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome
	Molecular Function	Integrin Binding Involved In Cell-matrix Adhesion	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Immune Response Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Heterotypic Cell-cell Adhesion Receptor Clustering Leukocyte Tethering Or Rolling Positive Regulation Of Lymphocyte Migration	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Anatomical Structure Morphogenesis Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus System Development Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis
Pathways			Degradation of the extracellular matrix Cell surface interactions at the vascular wall Hyaluronan metabolism Integrin cell surface interactions Hyaluronan degradation Neutrophil degranulation Interferon gamma signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs			Bivatuzumab Hyaluronic acid
Diseases			Gastric cancer
GWAS			Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 23273568 26502338 27399966 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 22561518 27723757)
Interacting Genes		5 interacting genes: CD44 ITGA4 ITGB7 PIGV STK11	70 interacting genes: ABCB1 ABCB5 AKT1 ANK1 ANXA1 ARHGEF1 ARHGEF12 ARNT BDNF CAT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK CSTF3 DMP1 DPT EGFR EPB41 EPHA2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK LMO2 MADCAM1 MAP2K3 MAP2K5 MAP3K13 MDM4 MET MMP1 MMP7 MMP9 NF2 NONO PDGFRA PKN1 RAF1 RIMS2 SELE SPP1 SRC SRD5A1 SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL
Entrez ID		8174	960
HPRD ID		00035	00115
Ensembl ID		ENSG00000099866	ENSG00000026508
Uniprot IDs		Q13477	P16070
PDB IDs		1BQS 1GSM 4HBQ 4HC1 4HCR 4HD9	1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
Enriched GO Terms of Interacting Partners?		Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Leukocyte Cell-cell Adhesion Immune Response In Gut-associated Lymphoid Tissue Cell-matrix Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Integrin Complex Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Focal Adhesion Cell-cell Adhesion Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Negative Regulation Of Protein Homodimerization Activity Cell Adhesion Molecule Binding Mannosyltransferase Complex Integrin-mediated Signaling Pathway Positive Regulation Of Monocyte Aggregation Cell Surface Regulation Of Signal Transduction By P53 Class Mediator Macrophage Migration Inhibitory Factor Receptor Complex Developmental Cell Growth Alpha-1,6-mannosyltransferase Activity Immune System Process Developmental Growth Involved In Morphogenesis Integrin Binding Cell Surface Receptor Signaling Pathway Monocyte Aggregation Integrin Alpha4-beta1 Complex Axonogenesis Intracellular Protein-containing Complex GPI Mannosyltransferase Activity Extracellular Exosome Cell Adhesion Positive Regulation Of Vesicle Transport Along Microtubule Cell Migration C-X3-C Chemokine Binding Leukocyte Migration LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Diapedesis Cell-cell Adhesion Mediated By Integrin Cell Motility Neuron Projection Morphogenesis Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Projection Morphogenesis	Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Intracellular Signal Transduction Protein Phosphorylation Animal Organ Development Developmental Process Regulation Of Growth Cellular Developmental Process Response To Growth Factor Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process ATP Binding Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Developmental Process Cell Migration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Growth Regulation Of Cell Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death
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