NDEL1 and PARD6G

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		NDEL1	PARD6G
Description		nudE neurodevelopment protein 1 like 1	par-6 family cell polarity regulator gamma
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Synaptic Vesicle Axon Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Axon Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Beta-tubulin Binding	Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Neuron Migration Inner Cell Mass Cell Proliferation Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Cell Differentiation Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Vesicle Transport Along Microtubule Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Ruffle Assembly Neuron Projection Extension	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Regulation Of Cellular Localization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Tight junction interactions
Drugs
Diseases
GWAS
Interacting Genes		85 interacting genes: ABI3 ACTB AIMP2 AKAP9 ANK2 APP BMI1 BORCS6 BRK1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 LUC7L2 MAGEA11 MBIP MED11 MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PARVG PICK1 PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TUBB USP2 XPA YWHAE YWHAG ZC2HC1C ZNF10 ZNF12 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF250 ZNF260 ZNF264 ZNF3 ZNF35 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF662 ZNF707 ZNF844 ZNF91	11 interacting genes: AKAP9 CASK CDC42 DMRTB1 KIFAP3 NDEL1 PARD3 PRKCI PRKCZ RAC1 RBM14
Entrez ID		81565	84552
HPRD ID		06340	10138
Ensembl ID		ENSG00000166579	ENSG00000178184
Uniprot IDs		A6NIZ0 Q9GZM8	Q9BYG4
PDB IDs		2V66
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Cytoskeleton Microtubule Cell Division Kinesin Complex Microtubule Binding Microtubule Cytoskeleton Organization Cytoskeleton Organization Centrosome Nucleus Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of RNA Biosynthetic Process DNA Binding Cytoskeleton-dependent Intracellular Transport Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Maintenance Of Location In Cell Organelle Organization Kinesin Binding Maintenance Of Location Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasmic Microtubule Organization Organelle Localization Acetylcholine Receptor Activator Activity Microtubule-based Movement Regulation Of Heart Rate By Cardiac Conduction Metal Ion Binding Establishment Of Organelle Localization Regulation Of Cell Cycle Microtubule Organizing Center Organization Central Region Of Growth Cone Protein Binding Cardiac Conduction Protein Kinase C Binding Retrograde Axonal Transport Presynapse Kinetochore Supramolecular Fiber Organization Maintenance Of Protein Location In Cell Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Motor Activity	PAR Polarity Complex Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Microtubule-based Process Establishment Of Cell Polarity Cytoskeleton Organization Centrosome Localization Organelle Organization Tight Junction Cell-cell Junction Organization Cell-cell Junction Cell Leading Edge G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Axon Hillock Cellular Localization Glutamatergic Synapse Thioesterase Binding Establishment Of Organelle Localization Neuron Projection Morphogenesis Cell Projection Morphogenesis Organelle Transport Along Microtubule Intracellular Protein Localization Microtubule Organizing Center Positive Regulation Of Ruffle Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Projection Organization Bicellular Tight Junction Cerebral Cortex Radially Oriented Cell Migration GTP-dependent Protein Binding Regulation Of Cell Adhesion Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Organelle Localization Establishment Of Epithelial Cell Polarity Transport Along Microtubule Phagocytosis, Engulfment Cell Junction Organization Regulation Of Ruffle Assembly Cerebral Cortex Cell Migration Microtubule Nucleation Cell Cortex Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cytoskeleton Organization
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