ZBP1 and PLXDC2

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ZBP1	PLXDC2
Description		Z-DNA binding protein 1	plexin domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Membrane
	Molecular Function	DNA Binding Left-handed Z-DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Necroptotic Process Pyroptotic Inflammatory Response Necroptotic Signaling Pathway Execution Phase Of Necroptosis Antiviral Innate Immune Response Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN RIP-mediated NFkB activation via ZBP1 Regulation of innate immune responses to cytosolic DNA Potential therapeutics for SARS
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075) Verbal declarative memory ( 25648963)	Abdominal aortic calcification levels ( 31659325) Activated partial thromboplastin time ( 29403010) Blood protein levels ( 30072576) Bone mineral density (Ward's triangle area) ( 27397699) Bronchopulmonary dysplasia ( 23897914) Diabetic retinopathy ( 21310492) Hair color ( 26926045) Heel bone mineral density ( 28869591 30598549) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Non-HDL cholesterol levels ( 32902719) Photic sneeze reflex ( 27182965) Plasma factor V levels in venous thrombosis ( 31271701) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Proteinuria and chronic kidney disease ( 26420894) Prothrombin time ( 29403010) Pulse pressure ( 27841878 30578418) Retinal detachment or retinal break ( 31816047) Total cholesterol levels ( 32902719)
Interacting Genes		10 interacting genes: APOE CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIM34 TRIP6	2 interacting genes: CLK1 ZBP1
Entrez ID		81030	84898
HPRD ID		09484	08440
Ensembl ID		ENSG00000124256	ENSG00000120594
Uniprot IDs		Q9H171	Q6UX71
PDB IDs		2L4M 2LNB 3EYI 4KA4
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Viral Process White Fat Cell Differentiation Viral Genome Replication Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance NAD Binding Transcription Coregulator Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transcription Corepressor Binding Transcription Repressor Complex Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Ubiquitin Protein Ligase Activity Intermediate-density Lipoprotein Particle Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipoprotein Transport Negative Regulation Of Dendritic Spine Maintenance Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Very-low-density Lipoprotein Particle Clearance Multivesicular Body, Internal Vesicle Positive Regulation Of Phospholipid Efflux Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Intracellular Signal Transduction AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Triglyceride-rich Lipoprotein Particle Clearance Positive Regulation Of Dendritic Spine Maintenance Regulation Of Plasma Lipoprotein Particle Levels Chylomicron Remnant Clearance Fat Cell Differentiation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Biosynthetic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intracellular Signal Transduction Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Lipoprotein Particle Binding Virion Assembly	Left-handed Z-DNA Binding Execution Phase Of Necroptosis Double-stranded RNA Adenosine Deaminase Activity Regulation Of Interleukin-1-mediated Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Necroptotic Process Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Necroptotic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Type I Interferon-mediated Signaling Pathway Pyroptotic Inflammatory Response Regulation Of Programmed Necrotic Cell Death Defense Response To Fungus Positive Regulation Of Cytokine-mediated Signaling Pathway Response To Fungus Positive Regulation Of Response To Cytokine Stimulus Double-stranded RNA Binding Antiviral Innate Immune Response
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