TUBB1 and PRELID3B

		TUBB1	PRELID3B
Description		tubulin beta 1 class VI	PRELI domain containing 3B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Extracellular Exosome Mitotic Spindle	Mitochondrion Mitochondrial Intermembrane Space
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding Metal Ion Binding	Protein Binding Phosphatidic Acid Transfer Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Platelet Formation Thyroid Gland Development Microtubule Polymerization Spindle Assembly Thyroid Hormone Transport Platelet Aggregation	Phospholipid Transport Intermembrane Lipid Transfer
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Vindesine Paclitaxel Docetaxel Epothilone D Patupilone CYT997 ZEN-012 Cabazitaxel Eribulin Milataxel Phenethyl Isothiocyanate
Diseases
GWAS		Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean platelet volume ( 22139419 27863252 32888494) Platelet count ( 22423221 32888494 29403010 27863252 24777453) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		3 interacting genes: CIMIP1 PRELID3B TTK	1 interacting genes: TUBB1
Entrez ID		81027	51012
HPRD ID		18243	12771
Ensembl ID		ENSG00000101162	ENSG00000101166
Uniprot IDs		Q9H4B7	Q9Y3B1
PDB IDs			6I4Y
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Meiotic Spindle Midzone Repair Of Mitotic Kinetochore Microtubule Attachment Defect Meiotic Spindle Checkpoint Signaling Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Female Meiosis Chromosome Segregation Kinetochore Binding Phosphatidic Acid Transfer Activity Negative Regulation Of Meiotic Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Meiotic Chromosome Segregation Protein Localization To Kinetochore Negative Regulation Of Meiotic Cell Cycle Protein Serine/threonine/tyrosine Kinase Activity Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Intermembrane Lipid Transfer Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Mitotic Nuclear Division Protein Localization To Chromosome, Centromeric Region Protein Localization To Cytoskeleton Nuclear Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Meiotic Cell Cycle Negative Regulation Of Reproductive Process Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Chromosome Organization Regulation Of Chromosome Separation Mitochondrial Intermembrane Space Phospholipid Transport Nuclear Division Mitotic Spindle Organization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Microtubule Polymerization Platelet Formation Thyroid Gland Development Thyroid Hormone Transport Microtubule Polymerization Or Depolymerization Platelet Aggregation Structural Constituent Of Cytoskeleton Hormone Transport Spindle Assembly Intercellular Bridge Homotypic Cell-cell Adhesion Protein Polymerization Mitotic Spindle Mitotic Cell Cycle Spindle Organization Gland Development Myeloid Cell Differentiation Membraneless Organelle Assembly Microtubule Cytoskeleton
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