FXR1 and ACLY

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		FXR1	ACLY
Description		FMR1 autosomal homolog 1	ATP citrate lyase
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleolus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Axon Dendrite Ribonucleoprotein Granule Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Costamere Dendritic Spine Intracellular Membraneless Organelle Synapse Perinuclear Region Of Cytoplasm Presynapse Postsynapse Glutamatergic Synapse	Extracellular Region Nucleoplasm Cytoplasm Cytosol Membrane Azurophil Granule Lumen Ciliary Basal Body Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Translation Regulator Activity Protein Heterodimerization Activity Molecular Condensate Scaffold Activity	Nucleotide Binding Catalytic Activity ATP Citrate Synthase Activity Protein Binding ATP Binding Transferase Activity Metal Ion Binding Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer
	Biological Process	Cytoplasmic Translational Initiation Regulation Of Translation Apoptotic Process Spermatogenesis Spermatid Development Muscle Organ Development Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Dentate Gyrus Development Cell Differentiation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rho Protein Signal Transduction Regulation Of MRNA Stability Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development Negative Regulation Of Inflammatory Response Regulation Of Neurogenesis MRNA Transport Nuclear Pore Complex Assembly Nuclear Pore Localization Regulation Of Synaptic Transmission, Glutamatergic Skeletal Muscle Organ Development Muscle Structure Development MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MiRNA-mediated Gene Silencing	Acetyl-CoA Biosynthetic Process Citrate Metabolic Process Oxaloacetate Metabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process Negative Regulation Of Ferroptosis
Pathways		Signaling by BRAF and RAF1 fusions	ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis
Drugs			Bempedoic acid
Diseases
GWAS		Bipolar disorder and eating disorder ( 26433762) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eating disorder in bipolar disorder ( 26433762) Mastocytosis ( 32752121) Metabolite levels ( 23823483) Schizophrenia ( 19571811 25056061 29483656 30285260)	High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		264 interacting genes: ABI1 ACLY ACOT7 ACTB ACTN1 ACTN2 ADAMTSL4 AHCY ALAS1 ANKRD40 ANKS3 AP1M1 APC2 ARHGAP22 ARHGEF7 ATN1 AXIN1 AXIN2 BCKDK BEND5 BHLHE40 BICD1 BLK BLTP3B BTBD2 BTBD6 BYSL C1orf35 CA10 CACTIN-AS1 CALCOCO1 CAMK2A CAMK2B CAMK2G CAPN3 CBS CBX8 CCAR2 CCBE1 CCDC187 CCDC92 CCN3 CD86 CDC7 CDKL3 CDR2 CDYL CEP126 CEP72 CEP89 CHRD CIRSR COIL CORO1A CORO1B CORO6 CPLANE1 CRMP1 CSNK2A1 CSNK2B CWF19L2 CYFIP2 DCTD DCTN1 DCTN2 DCTPP1 DEAF1 DHX15 DNAJA3 DNM2 ECH1 ECHS1 ECM1 EDC4 EFEMP2 EGFL7 EIF3A ELOA ENO1 ERCC6 ERG28 ERVFRD-1 ESCO2 EVL FAM161A FAM90A1 FBLN1 FLAD1 FLNB FMR1 FTH1 FXR2 GBP2 GFAP GLYR1 GOLGA2 GOLGA3 GPSM2 GRIA2 GRIP1 GRIP2 GRIPAP1 HIVEP1 HLA-DRB5 HMG20A HNRNPH2 HNRNPM HNRNPUL1 HOMER2 HOMER3 HSPB1 IK IL1RAP IMPDH2 INA JAKMIP1 KAZN KCNN1 KCTD1 KCTD13 KEAP1 KHDRBS1 KHDRBS3 KIAA1549L KIF17 KIF9 KRT18 LAP3 LNX1 LPP LRIF1 LRSAM1 LUC7L2 LZTS2 MAD1L1 MAGED1 MAGOH MAGOHB MAPK7 MAPK8IP3 MAPKBP1 MBIP MCRS1 MFAP1 MLLT1 MOAP1 MRPL19 MSANTD3 MTUS2 MVP MX1 MYH10 MYH9 MYO5B N4BP3 NBPF15 NECAB2 NECAB3 NEFL NEIL3 NKD2 NME1 NME1-NME2 NME3 P3H2 PAFAH1B3 PAICS PCCB PCED1A PDE9A PHC1P1 PHC2 PHLDB1 PKM PML PNMA1 POLR2H PPHLN1 PPP1R12C PRAM1 PRKCSH PRPF31 PRR13 PRSS23 PSMC3 PSMC5 PSME1 PSME3 PYCR1 PYCR2 PYCR3 RABAC1 RALYL RBM26 RBM45 RCBTB2 RPIA RUSC2 SAFB2 SAMD1 SCMH1 SEPTIN2 SERINC5 SERTAD1 SF3B2 SFPQ SH3GL2 SH3GLB2 SHANK1 SHARPIN SLC48A1 SLIT1 SMN1 SNURF SORBS3 SOX5 SPECC1 SPRY1 SPRY2 SRPK2 SSNA1 SST STK16 STUB1 SUFU SYT6 TACC2 TASOR2 TBC1D22B TCEA2 TDRD7 TLE5 TMPO TNFAIP1 TRAF2 TRAP1 TRIM3 TRIOBP TRPM1 TSN TTLL5 TUBB UBAP2L UBP1 USP46 USP7 UXS1 VIM VPS51 VWF WASH6P WEE2-AS1 WRNIP1 YAP1 YES1 YY1AP1 ZFTRAF1 ZMAT2 ZNF212 ZNF417 ZNF423 ZNF438 ZNF71 ZNF821	10 interacting genes: APP CDKN2A CEBPA DDIAS FXR1 GSK3B HGS KLHL25 PRKACA USP7
Entrez ID		8087	47
HPRD ID		02892	00155
Ensembl ID		ENSG00000114416	ENSG00000131473
Uniprot IDs		E7EU85 P51114	P53396
PDB IDs		2CPQ 3KUF 3O8V	3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET 6HXH 6HXK 6HXL 6HXM 6O0H 6POE 6POF 6QFB 6UI9 6UIA 6UUW 6UUZ 6UV5 6Z2H 7LIW 7LJ9 7LLA 7RIG 7RKZ 7RMP 8G1E 8G1F 8G5C 8G5D
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytosol Cytoplasm Cytoskeleton Protein Binding Regulation Of Proteolysis Cytoskeleton Organization Postsynaptic Cytoskeleton Organization Centrosome Nucleoplasm Protein Domain Specific Binding Regulation Of Proteasomal Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Pyrroline-5-carboxylate Reductase Activity Nucleus Neuron Projection Actin Filament Organelle Organization Synapse Positive Regulation Of Proteolysis Mitotic Spindle Pole RNA Splicing, Via Transesterification Reactions Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Protein Metabolic Process L-proline Biosynthetic Process RNA Splicing PcG Protein Complex MRNA Processing Stress Fiber MRNA Splicing, Via Spliceosome Microtubule Cytoskeleton Organization Supramolecular Fiber Organization Nervous System Development Postsynaptic Actin Cytoskeleton Organization Protein Homodimerization Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Protection Cell Cortex U2-type Precatalytic Spliceosome Bud Elongation Involved In Lung Branching Glutamate Receptor Signaling Pathway Structural Constituent Of Cytoskeleton Postsynaptic Density Microtubule Binding Crotonyl-CoA Hydratase Activity Uropod Organization Protein Kinase Binding RNA Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process GTP Biosynthetic Process	Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Export From Nucleus Negative Regulation Of Catabolic Process Regulation Of Long-term Synaptic Potentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Proteasomal Protein Catabolic Process Postsynapse Regulation Of Developmental Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process P53 Binding Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intracellular Transport TOR Signaling Negative Regulation Of Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Calcium-mediated Signaling Positive Regulation Of Gene Expression Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Developmental Process Regulation Of Circadian Rhythm Negative Regulation Of Small Molecule Metabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Translation Intracellular Signaling Cassette Regulation Of Gene Expression Negative Regulation Of Signaling Positive Regulation Of Cell Differentiation Negative Regulation Of Cell Communication Negative Regulation Of Proteolysis Regulation Of Intracellular Protein Transport
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