RASSF7 and NPAS2

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		RASSF7	NPAS2
Description		Ras association domain family member 7	neuronal PAS domain protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Centriolar Satellite	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol CLOCK-BMAL Transcription Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Apoptotic Process Signal Transduction	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Response To Xenobiotic Stimulus Regulation Of Gene Expression Circadian Regulation Of Gene Expression Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Rhythmic Process Response To Redox State Positive Regulation Of Behavioral Fear Response
Pathways			BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 26502338)	Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31798171 31959993) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Obsessive-compulsive traits ( 33531474) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: CHMP1B DISC1 MET NCK2 NPAS2 SNAP29	29 interacting genes: ARNT ARNT2 BMAL1 BPIFA1 CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 INCA1 KAT2B NCK2 NCOA3 NGLY1 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 UBAP2 ZSCAN1
Entrez ID		8045	4862
HPRD ID		00878	09137
Ensembl ID		ENSG00000099849	ENSG00000170485
Uniprot IDs		Q02833	A2I2P5 Q99743
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Projection Assembly Plasma Membrane Bounded Cell Projection Assembly Autophagosome Maturation Autophagosome Membrane Hepatocyte Growth Factor Receptor Activity Positive Regulation Of Protein Polymerization Regulation Of Cytoskeleton Organization Vesicle Fusion Organelle Membrane Fusion Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule-based Process Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Cellular Component Organization Semaphorin Receptor Activity Regulation Of Microtubule Cytoskeleton Organization Endothelial Cell Morphogenesis Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Regulation Of Actin Filament Organization Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Cytoskeleton Organization Hepatocyte Growth Factor Receptor Signaling Pathway CLOCK-BMAL Transcription Complex Positive Regulation Of Behavioral Fear Response Regulation Of Behavioral Fear Response Positive Regulation Of Fear Response Response To Redox State Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Postsynaptic Density Immunological Synapse Formation Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Translation In Response To Stress Cellular Component Assembly Cell Projection Organization Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Vesicle Organization Protein-containing Complex Disassembly Cilium Assembly Membrane Fusion Organelle Assembly Autophagy Vesicle Fusion To Plasma Membrane Cilium Organization Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane	Chromatin Transcription Regulator Complex Intracellular Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Nuclear Receptor Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity Regulation Of Metabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of DNA-templated Transcription Aryl Hydrocarbon Receptor Binding Regulation Of RNA Biosynthetic Process Aryl Hydrocarbon Receptor Complex Rhythmic Process Histone Acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Metabolic Process Nuclear Receptor Activity DNA Binding Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Acetyltransferase Activity Hormone-mediated Signaling Pathway Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process
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