WDR61 and DNAJA4

Data Source:
HPRD (in vivo)

		WDR61	DNAJA4
Description		WD repeat domain 61	DnaJ heat shock protein family (Hsp40) member A4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Transcriptionally Active Chromatin Ski Complex	Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Wnt Signaling Pathway Protein Ubiquitination Exonucleolytic Catabolism Of Deadenylated MRNA Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Histone H3-K79 Methylation	Response To Heat Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Protein Refolding Negative Regulation Of Inclusion Body Assembly
Pathways		Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	HSP90 chaperone cycle for steroid hormone receptors (SHR)
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Reticulocyte count ( 32888494)	Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		11 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ	3 interacting genes: BANP ERG SH3BP4
Entrez ID		80349	55466
HPRD ID		15236	09920
Ensembl ID		ENSG00000140395	ENSG00000140403
Uniprot IDs		H0YL19 Q9GZS3	Q69YX3 Q8WW22
PDB IDs		3OW8 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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