KCNIP4 and KCND2

Number of citations of the paper that reports this interaction (PubMedID 11847232)
0

Data Source:
HPRD (in vivo)

		KCNIP4	KCND2
Description		potassium voltage-gated channel interacting protein 4	potassium voltage-gated channel subfamily D member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Dendritic Spine Perikaryon Plasma Membrane Raft Synapse Postsynaptic Membrane Anchoring Junction Kv4.2-KChIP2 Channel Complex Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Action Potential Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Neuronal Action Potential Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Locomotor Rhythm Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Membrane Repolarization
Pathways		Phase 1 - inactivation of fast Na+ channels	Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels
Drugs			Enflurane Disopyramide Imipramine Promethazine Miconazole Dalfampridine
Diseases
GWAS		Appendicular lean mass ( 33097823) Cadmium levels ( 26025379) Colorectal cancer ( 29228715) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 26169577) Diverticular disease ( 30177863) Lingual gyrus volume ( 31530798) Obesity-related traits ( 23251661) Parkinson disease and lewy body pathology ( 25663231) Post bronchodilator FEV1/FVC ratio ( 26634245) Postburn scar height ( 30595539) Rheumatoid arthritis ( 21156761) Suicidal ideation ( 20877300)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Alcohol and nicotine co-dependence ( 22488850) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969)
Interacting Genes		11 interacting genes: APP ASPH COL1A2 GOLGA7 IL17A KCND2 LITAF MEOX2 PSEN1 PSEN2 TRH	9 interacting genes: DLG4 DPP10 FLNC IL16 KCNIP1 KCNIP2 KCNIP4 MET NCS1
Entrez ID		80333	3751
HPRD ID		12184	09254
Ensembl ID		ENSG00000185774	ENSG00000184408
Uniprot IDs		A8K4N3 Q3YAB7 Q6PIL6	A4D0V9 Q9NZV8
PDB IDs			7E7Z 7E83 7E84 7E87 7E8B 7E8E 7E8H 7F0J 7F3F 7UK5 7UKC 7UKD 7UKE 7UKF 7UKG 7UKH
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Astrocyte Activation Involved In Immune Response Aspartic Endopeptidase Activity, Intramembrane Cleaving Synaptic Membrane Gamma-secretase Complex Positive Regulation Of Protein Transport Notch Receptor Processing Amyloid-beta Formation Neuron Projection Maintenance Skin Morphogenesis Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein Trimerization Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid Fibril Formation Astrocyte Activation Regulation Of Calcium Ion Transmembrane Transport Inorganic Ion Homeostasis Positive Regulation Of Glycolytic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Positive Regulation Of Amino Acid Transport Amyloid Precursor Protein Metabolic Process Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Tumor Necrosis Factor Production Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Protein Localization Early Endosome Membrane Positive Regulation Of ATP Metabolic Process Locomotory Behavior Positive Regulation Of DNA-templated Transcription Membrane Protein Proteolysis Dendritic Shaft Calcium Ion Homeostasis Neuron Projection Organization Regulation Of Biological Quality Regulation Of Calcium Ion Transport Positive Regulation Of RNA Metabolic Process Cell-cell Signaling Protein Complex Oligomerization Regulation Of Blood Circulation Cellular Response To Amyloid-beta Signaling	Voltage-gated Potassium Channel Complex Potassium Channel Regulator Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Complex Regulation Of Transport Transmembrane Transporter Binding Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Dendrite Potassium Ion Transport Membrane Repolarization Metal Ion Transport Protein Localization To Cell Periphery Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Calcium Ion Binding Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Protein Localization To Membrane P2Y1 Nucleotide Receptor Binding Hepatocyte Growth Factor Receptor Activity Trans-synaptic Signaling Synaptic Signaling Monoatomic Ion Transport Synapse Protein Phosphatase Binding Kv4.2-KChIP2 Channel Complex Kv4.3-KChIP1 Channel Complex Regulation Of Signal Transduction Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Positive Regulation Of Neutrophil Activation Transmembrane Transport Localization Within Membrane Positive Regulation Of Potassium Ion Export Across Plasma Membrane Clustering Of Voltage-gated Potassium Channels A-type (transient Outward) Potassium Channel Activity AMPA Glutamate Receptor Clustering Regulation Of System Process Neuroligin Family Protein Binding Positive Regulation Of Chemotaxis
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