ADAM33 and NCR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAM33	NCR1
Description		ADAM metallopeptidase domain 33	natural cytotoxicity triggering receptor 1
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GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane SWI/SNF Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Proteolysis	Immune Response-regulating Signaling Pathway Cellular Defense Response Signal Transduction Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Regulation of CDH11 function	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Asthma
GWAS		Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)	Blood protein levels ( 30072576) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Interacting Genes		33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21	8 interacting genes: ADAM33 APP CD247 CD59 FCER1G RHOU TMEM229B TMEM50B
Entrez ID		80332	9437
HPRD ID		06173	05167
Ensembl ID		ENSG00000149451	ENSG00000189430
Uniprot IDs		A2A2L3 Q9BZ11	A0A0A0MQZ0 A0A0A0MR94 A0A0A0MTU0 O76036
PDB IDs		1R54 1R55	1OLL 1P6F 6IAP
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane	Fc-gamma Receptor III Complex Myeloid Leukocyte Activation Plasma Membrane Protein Complex Positive Regulation Of Protein Localization To Cell Surface Leukocyte Activation Cell Activation Fc-gamma Receptor Signaling Pathway Regulation Of Protein Localization To Cell Surface Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding External Side Of Plasma Membrane Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Fc Receptor Signaling Pathway Tertiary Granule Membrane IgE Receptor Activity Acetylcholine Receptor Activator Activity Positive Regulation Of Immune System Process PTB Domain Binding Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Membrane Regulation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Bacterium Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Vesicle-mediated Transport Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Localization Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune Effector Process Immune System Process Activation Of Immune Response Gamma-delta T Cell Receptor Complex Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet
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