EFHD1 and RAB27B

		EFHD1	RAB27B
Description		EF-hand domain family member D1	RAB27B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Calcium Ion Sensor Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Neuron Projection Development Regulation Of Cellular Hyperosmotic Salinity Response	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways			Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 34315874 29403010 33547301) Coronary artery disease ( 32469254) Gamma glutamyl transferase levels ( 33339817 29403010) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Refractive error ( 32231278) Schizophrenia ( 30285260 29483656 25056061)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		2 interacting genes: PSEN1 RAB27B	18 interacting genes: CNPY2 DHPS EFHD1 GORASP2 MEX3C MLPH MYRIP NR2E1 RPH3A RPH3AL SEC11A STARD6 SYTL1 SYTL2 SYTL4 TUFT1 UNC13D WDR7
Entrez ID		80303	5874
HPRD ID		13265	04846
Ensembl ID		ENSG00000115468	ENSG00000041353
Uniprot IDs		Q8WYH2 Q9BUP0	O00194
PDB IDs			2F7S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of L-glutamate Import Across Plasma Membrane Sequestering Of Calcium Ion Skin Morphogenesis Endoplasmic Reticulum Calcium Ion Homeostasis Synaptic Vesicle Targeting Protein Catabolic Process At Postsynapse Regulation Of L-glutamate Import Across Plasma Membrane Amyloid Precursor Protein Catabolic Process Vesicle Targeting Myeloid Dendritic Cell Differentiation Regulation Of Receptor Recycling Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Receptor Recycling Neuron Projection Maintenance Regulation Of Amyloid Fibril Formation Brain Morphogenesis Endosome Smooth Endoplasmic Reticulum L-glutamate Import Across Plasma Membrane Amyloid-beta Metabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Synaptic Vesicle Cycle Choline Transport Cajal-Retzius Cell Differentiation Negative Regulation Of DNA Binding Ciliary Rootlet Amyloid-beta Formation Negative Regulation Of Core Promoter Binding Astrocyte Activation Regulation Of Resting Membrane Potential Gamma-secretase Complex Positive Regulation Of Amino Acid Transport Notch Receptor Processing Aspartic Endopeptidase Activity, Intramembrane Cleaving Growth Factor Receptor Binding Negative Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Vesicle-mediated Transport Dorsal/ventral Neural Tube Patterning Import Into Cell Positive Regulation Of Glycolytic Process Positive Regulation Of Transport Aspartic-type Endopeptidase Activity Regulation Of Transcription Regulatory Region DNA Binding Astrocyte Activation Involved In Immune Response Amyloid Precursor Protein Metabolic Process Neural Retina Development Cerebral Cortex Neuron Differentiation Trans-Golgi Network Transport Vesicle Protein Transport Along Microtubule	Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel
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