CDK5RAP3 and SRPRB

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		CDK5RAP3	SRPRB
Description		CDK5 regulatory subunit associated protein 3	SRP receptor subunit beta
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Protein-containing Complex	Cytoplasm Endoplasmic Reticulum Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Protein Binding GTP Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Liver Development Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Brain Development Blood Circulation Cell Population Proliferation Regulation Of Phosphatase Activity Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Ribosome Disassembly Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Definitive Erythrocyte Differentiation Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Rescue Of Stalled Ribosome Positive Regulation Of Reticulophagy Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Protein Targeting To ER
Pathways			SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)	Alcohol consumption (transferrin glycosylation) ( 21665994) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Nicotine dependence symptom count ( 25555482) Red blood cell count ( 32888494)
Interacting Genes		13 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4 VHL	3 interacting genes: CDK5RAP3 RCHY1 UBC
Entrez ID		80279	58477
HPRD ID		12190	18105
Ensembl ID		ENSG00000108465	ENSG00000144867
Uniprot IDs		Q96JB5	Q549N5 Q9Y5M8
PDB IDs		8OHD 8OJ0 8OJ5 8QFC	7NFX
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber Cell Surface Receptor Signaling Pathway Regulation Of Postsynapse Organization Non-canonical NF-kappaB Signal Transduction Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Molecular Adaptor Activity Telencephalon Cell Migration Forebrain Cell Migration	Rescue Of Stalled Ribosome Ribosome Disassembly Protein Modification By Small Protein Conjugation Translational Elongation Organelle Disassembly Post-translational Protein Modification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Regulation Of Post-translational Protein Modification Positive Regulation Of Reticulophagy Definitive Erythrocyte Differentiation Regulation Of Reticulophagy Protein Modification Process Error-free Translesion Synthesis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Apoptotic Nuclear Changes Positive Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Protein Ufmylation Regulation Of Phosphatase Activity MDM2/MDM4 Family Protein Binding Protein Tag Activity Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Protein Ubiquitination Mitogen-activated Protein Kinase Binding Regulation Of Protein Modification Process Regulation Of Dephosphorylation Translesion Synthesis Proteolysis Involved In Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Protein Metabolic Process DNA Damage Response Postreplication Repair NF-kappaB Binding Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic G2 DNA Damage Checkpoint Signaling Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Metabolic Process DNA Synthesis Involved In DNA Repair
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