TM2D3 and TARS3

		TM2D3	TARS3
Description		TM2 domain containing 3	threonyl-tRNA synthetase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm
	Molecular Function		Nucleotide Binding Aminoacyl-tRNA Ligase Activity Threonine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Positive Regulation Of Notch Signaling Pathway Lateral Inhibition	Translation TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation TRNA Aminoacylation
Pathways
Drugs
Diseases
GWAS		Depression in multiple sclerosis (pre-diagnosis) ( 33296963) Triglyceride levels ( 32154731)
Interacting Genes		6 interacting genes: ERRFI1 LCOR LRRK1 PAXIP1 SELENOS TARS3	12 interacting genes: ARPC3 ARRDC4 ATF4 DNM1P46 DSCAM ECSIT LGALS14 LRRC28 RNF10 SELENOS TARS2 TM2D3
Entrez ID		80213	123283
HPRD ID		16554	15469
Ensembl ID		ENSG00000184277	ENSG00000185418
Uniprot IDs		B4DLL2 E7EPS7 H0YNS4 Q9BRN9	A2RTX5
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-specific Protease Binding Adipose Tissue Development Connective Tissue Development Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Cellular Response To Lipid Response To Estradiol Cellular Response To Insulin Stimulus Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Derlin-1-VIMP Complex Intracellular Signal Transduction Chorion Development Negative Regulation Of Protein Autophosphorylation Anatomical Structure Homeostasis Tissue Homeostasis Cellular Response To Peptide Hormone Stimulus Oviduct Epithelium Development Regulation Of Tumor Necrosis Factor Production Response To Insulin Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Response To Lipid Limb Joint Morphogenesis Cellular Response To Oxygen-containing Compound Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Macrophage Apoptotic Process Osteoclast Development MLL3/4 Complex Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Lung Vasculature Development Negative Regulation Of Cytokine Production Response To Peptide Hormone Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Lung Epithelium Development Cellular Response To Chemical Stress Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Cellular Response To Hormone Stimulus ER Overload Response Negative Regulation Of Acute Inflammatory Response
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