FUZ and KLK7

		FUZ	KLK7
Description		fuzzy planar cell polarity protein	kallikrein related peptidase 7
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Cell Projection Extracellular Exosome	Cornified Envelope Extracellular Region Extracellular Space Secretory Granule Epidermal Lamellar Body
	Molecular Function	Protein Binding Phosphatidylinositol Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Negative Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Embryonic Body Morphogenesis Protein Transport Vesicle-mediated Transport Neural Tube Development Cell Projection Organization Negative Regulation Of Cell Migration Intraciliary Transport Positive Regulation Of Cilium Assembly Embryonic Skeletal System Morphogenesis Cilium Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Neural Crest Formation Regulation Of Cilium Assembly Non-motile Cilium Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly Protein Maturation
Pathways		Hedgehog 'off' state	Degradation of the extracellular matrix Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs			L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
Diseases
GWAS			Blood protein levels ( 30072576) HDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		3 interacting genes: CPLANE2 DSCR9 KLK7	11 interacting genes: APP BAG4 CCND1 CDSN CHEK2 FUZ PTPN1 PTPRJ STK11 TGFB1 WT1
Entrez ID		80199	5650
HPRD ID		08662	05115
Ensembl ID		ENSG00000010361	ENSG00000169035
Uniprot IDs		E9PK12 Q9BT04	B4DHX9 P49862
PDB IDs		7Q3D	2QXG 2QXH 2QXI 2QXJ 3BSQ 5FAH 5Y9L 5YJK 6SHH 6SHI 6SJU 6Y4S
Enriched GO Terms of Interacting Partners?		Regulation Of Antibacterial Peptide Production Positive Regulation Of Antibacterial Peptide Production Protein Maturation Epidermal Lamellar Body Positive Regulation Of Antimicrobial Peptide Production Cell Adhesion Involved In Heart Morphogenesis Endocardial Cushion Fusion Positive Regulation Of Antimicrobial Humoral Response Positive Regulation Of Defense Response To Bacterium Regulation Of Antimicrobial Humoral Response Regulation Of Defense Response To Bacterium Cranial Skeletal System Development Positive Regulation Of Humoral Immune Response	Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Response To Ionizing Radiation Negative Regulation Of Cell Growth Response To Radiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Growth Vasculogenesis Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Cell Migration Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of MiRNA Transcription Regulation Of Cell Motility Regulation Of Growth Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Multicellular Organismal Process Protein Dephosphorylation Regulation Of MiRNA Metabolic Process Positive Regulation Of Mononuclear Cell Migration Regulation Of Endocytosis Response To Growth Factor Regulation Of Wnt Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Cycle Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Fibroblast Migration Negative Regulation Of Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Dephosphorylation Negative Regulation Of MAP Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Superoxide Anion Generation Regulation Of Multicellular Organismal Process Developmental Growth Involved In Morphogenesis
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