RNF34 and UBE2F

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		RNF34	UBE2F
Description		ring finger protein 34	ubiquitin conjugating enzyme E2 F (putative)
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Membrane Nuclear Body Nuclear Speck	Nucleus Cytosol
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding	Nucleotide Binding Protein Binding ATP Binding Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity NEDD8 Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Cold Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Defense Response To Virus
Pathways		Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Lean body mass ( 28552196)
Interacting Genes		17 interacting genes: APP APPBP2 DNAJA3 FLII IKBKG MAVS MKS1 NOD1 PHF7 RUBCN TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2F UBE2H	13 interacting genes: CUL1 DCUN1D1 DCUN1D2 DCUN1D5 LCN2 NAE1 PAX6 RBX1 RC3H1 RNF34 RNF7 TRIM2 UBA3
Entrez ID		80196	140739
HPRD ID		10509	14812
Ensembl ID		ENSG00000170633	ENSG00000184182
Uniprot IDs		A0A087WTM5 Q969K3	Q969M7
PDB IDs			2EDI 3FN1 4GBA
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Innate Immune Response Cytosol ATP Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Modification Process Proteasomal Protein Catabolic Process Proteolysis CARD Domain Binding Positive Regulation Of Interleukin-6 Production Nucleotide Binding Transferase Activity Positive Regulation Of Tumor Necrosis Factor Production Ubiquitin Ligase Complex Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Defense Response To Bacterium Immune System Process Protein Serine/threonine Kinase Binding Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Interleukin-6 Production Response To Other Organism Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Bacterium Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy Immune Response Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Innate Immune Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding	Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cullin Family Protein Binding Protein Modification Process NEDD8 Transferase Activity Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Polyubiquitination Protein Metabolic Process Regulation Of Protein Neddylation NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination NEDD8 Ligase Activity Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Modifier Activating Enzyme Activity Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Macromolecule Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Modification Process Cytoplasm Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Apoptotic Process Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Stress Response To Cytokine Response To Peptide Cellular Response To Interleukin-1 Positive Regulation Of Hippocampal Neuron Apoptotic Process
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