BICC1 and MAP1LC3C

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		BICC1	MAP1LC3C
Description		BicC family RNA binding protein 1	microtubule associated protein 1 light chain 3 gamma
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GO Annotations	Cellular Component	Cytoplasm	Autophagosome Membrane Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleic Acid Binding RNA Binding	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Kidney Development Determination Of Left/right Symmetry Heart Development Negative Regulation Of Canonical Wnt Signaling Pathway	Autophagosome Assembly Mitophagy Autophagy Response To Stress Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163 29403010) Chronotype ( 30696823) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 29403010 32888494) Hemoglobin levels ( 32327693) Intraocular pressure ( 31959993) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Manganese levels ( 26025379) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Midgestational circulating levels of PCBs ( 28235828) Morning person ( 30696823) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278 23396134) Serum uric acid levels ( 30993211 29403010) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Urate levels ( 31985003 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: CISD1 FAM13C GABARAP GABARAPL1 GABARAPL2 MAP1LC3C	41 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG13 ATXN3 BICC1 CALCOCO2 CAPN3 CDC37 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NCOR1 NEDD4 NIPBL OPRM1 OPTN PDLIM1 RESF1 RHOXF1 RUFY4 SAMM50 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 WDFY3 WDR81 ZNF24
Entrez ID		80114	440738
HPRD ID		18993	14226
Ensembl ID		ENSG00000122870	ENSG00000197769
Uniprot IDs		Q9H694	Q9BXW4
PDB IDs		4RQM 4RQN 6GY4	2NCN 3VVW 3WAM 3WAP 5DPW
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly GABA Receptor Binding Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Beta-tubulin Binding Response To Starvation Cellular Response To Nutrient Levels Autophagy Ubiquitin Protein Ligase Binding Response To Nutrient Levels Organelle Assembly Cytoplasmic Vesicle Microtubule Protein-containing Complex Organization L-cysteine Transaminase Activity Cellular Response To Stress Positive Regulation Of Protein K48-linked Ubiquitination Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Microtubule Binding Endomembrane System Tat Protein Binding Protein Transport Glycophagy Cellular Component Assembly Aggrephagy Organelle Organization Protein Localization To Endoplasmic Reticulum Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Polyubiquitination Establishment Of Protein Localization Regulation Of Protein Catabolic Process Smooth Endoplasmic Reticulum Regulation Of Proteolysis Positive Regulation Of ATP-dependent Activity Glycogen Catabolic Process Golgi Apparatus Polysaccharide Catabolic Process	Autophagosome Positive Regulation Of Autophagy Regulation Of Autophagy Autophagy Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Catabolic Process Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Vacuole Organization Protein K48-linked Ubiquitination Regulation Of Intracellular Signal Transduction Cytosol Organelle Organization Regulation Of Cell Communication Cytoplasmic Vesicle Regulation Of Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Localization To Organelle Macroautophagy Regulation Of Protein Stability Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Innate Immune Response-activating Signaling Pathway Organelle Assembly Ubiquitin-dependent Protein Catabolic Process Protein Localization To Phagocytic Vesicle Regulation Of Autophagosome Maturation Modification-dependent Protein Catabolic Process Cytoplasm Regulation Of Gene Expression Intracellular Protein Localization Regulation Of Macromolecule Metabolic Process Suppression Of Viral Release By Host Autophagosome Membrane Regulation Of Signaling Activation Of Innate Immune Response Protein Monoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Macromolecule Biosynthetic Process Protein-macromolecule Adaptor Activity
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