CALD1 and LBR

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		CALD1	LBR
Description		caldesmon 1	lamin B receptor
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Myofibril Actin Cap	Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Lamina Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	Actin Binding Protein Binding Calmodulin Binding Tropomyosin Binding Myosin Binding Cadherin Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding Chromatin-protein Adaptor Activity
	Biological Process	Muscle Contraction Actin Filament Bundle Assembly	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process Neutrophil Differentiation Random Inactivation Of X Chromosome
Pathways		Smooth Muscle Contraction	Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity
Drugs
Diseases			HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Glaucoma (primary open-angle) ( 33627673) Hematocrit ( 32888494) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Red blood cell count ( 32888494) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Serum alkaline phosphatase levels ( 33547301)	Delirium ( 29631748) LDL cholesterol levels in HIV infection ( 33109212) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		15 interacting genes: CALM1 CALM2 CALM3 CDK1 GRB2 LBR MAPK3 POT1 PRKACA QKI RBFOX2 RNF10 SHC1 TERF1 TINF2	14 interacting genes: AKAP8L CALD1 CBX3 CBX5 CD81 FNBP4 H4C14 KPNB1 LMNB1 PRM1 SFTPD SRPK1 SRPK2 YWHAG
Entrez ID		800	3930
HPRD ID		00251	02488
Ensembl ID		ENSG00000122786	ENSG00000143815
Uniprot IDs		A0A140VKA0 E7EX44 E9PGZ1 Q05682	Q14739
PDB IDs			2DIG
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Shelterin Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Chromosome Organization Spindle Microtubule Nuclear Telomere Cap Complex Sperm Midpiece Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction G2/M Transition Of Mitotic Cell Cycle Telomere Capping Cell Cycle G2/M Phase Transition Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Positive Regulation Of Telomere Maintenance Calyx Of Held Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Telomere Maintenance Via Telomerase Catalytic Complex Regulation Of Calcium-mediated Signaling Spindle Negative Regulation Of Transporter Activity Regulation Of Striated Muscle Contraction Regulation Of Chromosome Organization Calcineurin-mediated Signaling Regulation Of Heart Rate Presynaptic Cytosol Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Myelin Sheath Regulation Of Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Positive Regulation Of DNA Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Sequestering Of Calcium Ion Telomere Assembly Negative Regulation Of Calcium Ion Transmembrane Transport	Chromatin Organization Nuclear Envelope Protein Localization To Organelle Nucleoplasm Chromatin Remodeling Heterochromatin Formation Nuclear Matrix Chromosome Sperm DNA Condensation Positive Regulation Of Viral Genome Replication Pericentric Heterochromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Chromosome Condensation Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Gene Expression Protein Domain Specific Binding RNA Binding Nuclear Inner Membrane Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Site Of DNA Damage Heterochromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Lysosome Positive Regulation Of Viral Process Epigenetic Regulation Of Gene Expression Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Gene Expression Structural Constituent Of Nuclear Lamina Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Protein Localization To Vacuole Myoblast Fusion Involved In Skeletal Muscle Regeneration Nucleus Organization Chromosome Organization Protein Kinase C Inhibitor Activity Chromatin Lock Complex Regulation Of Macromolecule Metabolic Process Actin Cap Regulation Of T Cell Mediated Immunity Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus RNA Splicing Nuclear Speck Organization Senescence-associated Heterochromatin Focus
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