TNIP3 and KPNA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNIP3	KPNA3
Description		TNFAIP3 interacting protein 3	karyopherin subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex Host Cell
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Inflammatory Response Toll-like Receptor 4 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Symbiont Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus
Pathways		Ovarian tumor domain proteases	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23468962) Multiple sclerosis ( 31604244)	Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triiodothyronine/thyroxine ratio ( 30824882)
Interacting Genes		26 interacting genes: BBS12 CCN3 CYSRT1 DAZAP2 FAM161A KPNA3 KRT40 KRTAP10-3 KRTAP10-8 LITAF LZTS2 MAGEA2 MAGEA2B MTUS2 NBPF19 NOTCH2NLA NTAQ1 PIBF1 PLSCR3 TAX1BP1 TCEANC TNIP1 TRIM55 TRIM63 UBC ZBTB8A	51 interacting genes: APOL6 ARNT ATM ATOSB BAHD1 CCDC102B CDKN1B COIL EPAS1 EPHA2 ERCC3 ESR2 FAM50B FTL GATA6 GRB10 GTF2H1 GTF2IRD1 HEXIM2 HIF1A HNRNPC HSPB1 KAT5 KPNB1 L3MBTL4 MAPK9 MAT2B MVP MYOD1 NFE2L2 NFKB1 NMNAT1 NRIP1 OGT POLR3C RAD52 RCC1 RPRD1A SLC5A11 SPMIP9 TGM2 TNIP3 TSSC4 UVSSA ZBTB24 ZCCHC10 ZCCHC12 ZFTRAF1 ZNF131 ZNF76 ZNF764
Entrez ID		79931	3839
HPRD ID		16268	03536
Ensembl ID		ENSG00000050730	ENSG00000102753
Uniprot IDs		Q96KP6	O00505
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Acetylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Transcription Coactivator Binding Negative Regulation Of RNA Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair DNA-binding Transcription Factor Activity Gene Expression Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cellular Response To Oxidative Stress Cellular Senescence Cellular Response To Oxygen-containing Compound Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA Double-strand Break Processing Embryonic Placenta Development Macromolecule Biosynthetic Process
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