ZBTB3 and IRF6

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZBTB3	IRF6
Description		zinc finger and BTB domain containing 3	interferon regulatory factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Keratinocyte Differentiation Skin Development Keratinocyte Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Limb Development Mammary Gland Epithelial Cell Differentiation Stem Cell Proliferation Cranial Skeletal System Development Negative Regulation Of Stem Cell Proliferation
Pathways			Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases			IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734) Systolic blood pressure ( 30224653)
Interacting Genes		24 interacting genes: ANKRD2 AP1M1 BIN1 EIF5B FOXM1 GATA4 GTF2A1L IKBKG IRF6 JADE2 LEF1 MYO15B NR3C1 PKNOX1 PPARG PROX1 SKIL SMAD3 SMYD1 SSX3 SUPT5H THRA ZMYM2 ZNF556	5 interacting genes: CENPF IRF8 RFX3 TLX2 ZBTB3
Entrez ID		79842	3664
HPRD ID		15693	06227
Ensembl ID		ENSG00000185670	ENSG00000117595
Uniprot IDs		A0A6E1W9L1	G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Epithelial Cell Differentiation Animal Organ Development Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Domain Binding Positive Regulation Of Biosynthetic Process DNA-templated Transcription Myeloid Cell Differentiation Cell Differentiation DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Regulator Complex Gland Development Transdifferentiation LBD Domain Binding Chromatin Binding Tube Morphogenesis	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Plasmacytoid Dendritic Cell Differentiation Positive Regulation Of Type B Pancreatic Cell Development Type B Pancreatic Cell Maturation DNA Binding Plasmacytoid Dendritic Cell Activation Follicular B Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Ciliary Transition Fiber Pronucleus Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Dendrite Morphogenesis Germinal Center B Cell Differentiation Kinetochore Assembly Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Negative Regulation Of RNA Metabolic Process Kinetochore Organization Regulation Of Metabolic Process Endocrine Pancreas Development
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