NHEJ1 and XRCC4

Number of citations of the paper that reports this interaction (PubMedID 30017584)
53

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		NHEJ1	XRCC4
Description		non-homologous end joining factor 1	X-ray repair cross complementing 4
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Chromosome DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex	Condensed Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Protein Binding DNA End Binding DNA Polymerase Binding	DNA Binding Protein Binding Ligase Activity Enzyme Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Central Nervous System Development Response To Ionizing Radiation B Cell Differentiation T Cell Differentiation Immunoglobulin V(D)J Recombination Positive Regulation Of Ligase Activity	DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To X-ray Immunoglobulin V(D)J Recombination Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Protein Localization To Site Of Double-strand Break
Pathways		Nonhomologous End-Joining (NHEJ)	2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)
Drugs			S-(Dimethylarsenic)Cysteine
Diseases		Severe combined immunodeficiency with microcephaly, growth retardation, and sensitivity to ionizing radiation; NHEJ1 syndrome
GWAS		Appendicular lean mass ( 33097823) Height ( 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Thyroid stimulating hormone levels ( 32769997) Waist circumference adjusted for body mass index ( 34021172)	Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		3 interacting genes: ATM LIG4 XRCC4	23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 OGT PNKP PRKDC VIM
Entrez ID		79840	7518
HPRD ID		07784	15951
Ensembl ID		ENSG00000187736	ENSG00000152422
Uniprot IDs		H7C0G7 Q9H9Q4	Q13426 Q7Z763
PDB IDs		2QM4 2R9A 3Q4F 3RWR 3SR2 3W03 6ERG 6ERH 7LSY 7LT3 7NFC 7NFE 7ZYG 8BHV 8BHY 8BOT 8EZA 8EZB	1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO 7LSY 7LT3 7M3P 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB
Enriched GO Terms of Interacting Partners?		V(D)J Recombination Response To X-ray Somatic Cell DNA Recombination Double-strand Break Repair Via Nonhomologous End Joining DNA Ligase IV Complex Response To Ionizing Radiation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Double-strand Break Repair Cellular Response To Lithium Ion DNA Recombination Response To Lithium Ion Protein Localization To Site Of Double-strand Break Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Response To Radiation Somatic Diversification Of Immunoglobulins DNA Repair Response To Gamma Radiation Cellular Response To Ionizing Radiation DNA Metabolic Process DNA Damage Response Site Of Double-strand Break Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Neuron Apoptotic Process Ligase Activity Establishment Of Integrated Proviral Latency FHA Domain Binding Positive Regulation Of Cellular Component Organization Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Cellular Response To Radiation Chromosome, Telomeric Region Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cellular Response To Metal Ion Establishment Of Viral Latency Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity DNA Ligase (ATP) Activity DNA Ligase Activity Regulation Of Chromosome Organization Regulation Of Neuron Apoptotic Process Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination	Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA-dependent Protein Kinase-DNA Ligase 4 Complex Somatic Recombination Of Immunoglobulin Gene Segments Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Site Of Double-strand Break Protein Localization To Chromosome Somatic Cell DNA Recombination Single Strand Break Repair Somatic Diversification Of Immunoglobulins DNA Recombination Polynucleotide 3'-phosphatase Activity V(D)J Recombination DNA Ligase IV Complex Protein Localization To Site Of Double-strand Break Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Cellular Response To Stress Organelle Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Double-strand Break Repair Double-strand Break Repair Via Alternative Nonhomologous End Joining Nucleus Double-strand Break Repair Via Classical Nonhomologous End Joining Damaged DNA Binding Lymphoid Progenitor Cell Differentiation B Cell Activation Double-stranded RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA Repair Response To Stress Positive Regulation Of Double-strand Break Repair DNA Damage Checkpoint Signaling Telomere Maintenance Positive Regulation Of Chromosome Organization Sin3-type Complex PML Body Regulation Of DNA Metabolic Process DNA Endonuclease Activity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair-dependent Chromatin Remodeling
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