SNIP1 and NFATC2

Data Source:
BioGRID (affinity chromatography technology)

		SNIP1	NFATC2
Description		Smad nuclear interacting protein 1	nuclear factor of activated T cells 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol U2-type Precatalytic Spliceosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Phosphatase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II I-kappaB Kinase/NF-kappaB Signaling Production Of MiRNAs Involved In Gene Silencing By MiRNA	Negative Regulation Of Transcription By RNA Polymerase II Cytokine Production Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Myotube Cell Development Cell Migration Positive Regulation Of B Cell Proliferation Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Response To Drug Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II B Cell Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways			Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Asthma ( 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 28552196) Lymphocyte counts ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Molar-incisor hypomineralization ( 23918034) Monocyte count ( 32888494) Self-reported allergy ( 23817569) Sitting height ratio ( 25865494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 32499647 30718926) Urinary uric acid excretion ( 31993563) Weight ( 28552196) White matter microstructure in first episode schizophrenia (right anterior cingulate cortex) ( 28924203)
Interacting Genes		49 interacting genes: CDK6 CLK2 CLK3 CREBBP DVL2 DVL3 EIF3C EP300 ESRRG FAF1 GMEB1 GYS1 HIPK1 HIPK3 KRTAP10-6 MAX MYC PHF19 PIAS1 PIAS2 PIAS3 PIAS4 POU2F1 PRPF3 PRPF40A RELA SETDB1 SF3B1 SMAD1 SMAD2 SMAD4 SON SP100 SPANXN2 SRPK2 SRRM4 STK3 TDG TNIP1 TOPORS TSPYL2 TTC14 UBE2I ZBTB9 ZCCHC10 ZCCHC7 ZMYM2 ZMYM5 ZNF451	18 interacting genes: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ TAF9 VIM YWHAQ YWHAZ
Entrez ID		79753	4773
HPRD ID		06999	02730
Ensembl ID		ENSG00000163877	ENSG00000101096
Uniprot IDs		B1AK66 Q8TAD8	B5B2P4 Q13469
PDB IDs		5Z56 5Z57 5Z58 6FF7	1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF
Enriched GO Terms of Interacting Partners?
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