TBC1D17 and RAB5A

Number of citations of the paper that reports this interaction (PubMedID 16923123)
0

Data Source:
BioGRID (two hybrid)

		TBC1D17	RAB5A
Description		TBC1 domain family member 17	RAB5A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Autophagosome Cytosol Cytoplasmic Vesicle Recycling Endosome	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding GDP Binding
	Biological Process	Autophagy Protein Transport Retrograde Transport, Endosome To Golgi Regulation Of Cilium Assembly	Intracellular Protein Transport Endocytosis Phagocytosis Protein Transport Endosomal Transport Receptor Internalization Synaptic Vesicle Recycling Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Endosome Size Regulation Of Filopodium Assembly Canonical Wnt Signaling Pathway Membrane Fusion Amyloid-beta Clearance By Transcytosis Protein Localization To Early Endosome Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly
Pathways		TBC/RABGAPs	Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Respiratory syncytial virus (RSV) attachment and entry Factors involved in megakaryocyte development and platelet production
Drugs			L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS			Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)
Interacting Genes		20 interacting genes: ASCC2 CALCOCO1 CCT5 CDKN2D DHX29 FBL GABARAPL1 GPS1 GTF3C1 MAP1LC3A MAP1LC3B NIPSNAP1 OPTN RAB1A RAB5A RAB5B RAB5C SLC1A5 TAX1BP1 UBC	37 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 SNCA STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL WEE2-AS1
Entrez ID		79735	5868
HPRD ID		15471	01542
Ensembl ID		ENSG00000104946	ENSG00000144566
Uniprot IDs		Q9HA65	P20339
PDB IDs			1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1
Enriched GO Terms of Interacting Partners?		Mitophagy Autophagy Autophagy Of Mitochondrion Autophagosome Melanosome Plasma Membrane To Endosome Transport Cellular Response To Nitrogen Starvation Endomembrane System Phosphatidylethanolamine Binding Macroautophagy G Protein Activity Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Autophagosome Membrane Vacuole Organization Endocytic Vesicle GDP Binding Catabolic Process Extracellular Exosome Cytoplasmic Vesicle Ubiquitin Protein Ligase Binding Phospholipid Binding K63-linked Polyubiquitin Modification-dependent Protein Binding GTPase Activity Early Endosome Import Into Cell Microtubule Protein-containing Complex Disassembly GTP Binding Beta-tubulin Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Organelle Assembly Organelle Organization Cellular Response To Starvation Organelle Membrane Endosome Endocytosis Early Endosome Membrane Protein-macromolecule Adaptor Activity Response To Nutrient Levels Histone H2AQ104 Methyltransferase Activity JNK Cascade Glutamine Secretion Protein Localization To Phagocytic Vesicle Response To Starvation Cyclin D2-CDK4 Complex Box C/D Sno(s)RNA 3'-end Processing Intracellular Protein Transport Protein Localization To Early Endosome	GTPase Activator Activity Small GTPase Binding Vesicle-mediated Transport Endosome Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Endocytosis Cytoplasmic Vesicle Regulation Of Cellular Component Organization Cellular Localization Import Into Cell Intracellular Transport Regulation Of Cilium Assembly Endosomal Transport Small GTPase-mediated Signal Transduction Macropinosome Establishment Of Protein Localization Protein Transport Early Endosome Membrane Cytosol Establishment Of Localization In Cell Positive Regulation Of Pinocytosis Regulation Of Transport Early Endosome Regulation Of Organelle Assembly Cytoplasm Positive Regulation Of Macropinocytosis Regulation Of Cell Projection Assembly Endocytic Vesicle Membrane Fusion Positive Regulation Of Endocytosis Rab-protein Geranylgeranyltransferase Complex Phagocytic Vesicle Signal Transduction Intracellular Protein Localization Vesicle Fusion Retrograde Transport, Endosome To Golgi Protein Geranylgeranylation Organelle Membrane Fusion Ruffle Guanyl-nucleotide Exchange Factor Activity Synapse Adiponectin-activated Signaling Pathway Regulation Of Organelle Organization Protein Prenylation Organelle Fusion Cytosolic Transport Plasma Membrane To Endosome Transport Recycling Endosome Cell Projection
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