PARP8 and HTR6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PARP8	HTR6
Description		poly(ADP-ribose) polymerase family member 8	5-hydroxytryptamine receptor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Membrane Endoplasmic Reticulum Tubular Network	Plasma Membrane Cilium Membrane Dendrite Synapse
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Kinase Binding Protein Serine/threonine Kinase Activator Activity NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity
	Biological Process	Endoplasmic Reticulum Unfolded Protein Response Protein Auto-ADP-ribosylation	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein	Serotonin receptors G alpha (s) signalling events
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Callous-unemotional behaviour ( 23874384) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood ear infection ( 27182965) General risk tolerance (MTAG) ( 30643258) HOMA-B (corrected for HOMA-IR) ( 30369944) Myopia (pathological) ( 22685421) Type 2 diabetes ( 30718926 32499647) Verbal declarative memory ( 25648963)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		1 interacting genes: HTR6	32 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CD160 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		79668	3362
HPRD ID		07960	03066
Ensembl ID		ENSG00000151883	ENSG00000158748
Uniprot IDs		B2RB27 E9PFI7 Q8N3A8	P50406
PDB IDs			7XTB 7YS6 8JLZ
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Serotonin Receptor Signaling Pathway Histamine Receptor Activity Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cerebral Cortex Cell Migration Forebrain Cell Migration Telencephalon Cell Migration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of TOR Signaling Regulation Of TOR Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway	Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH
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